Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

BRCA1 encodes a tumor suppressor that is mutated in familial breast and ovarian cancers. Here, it is shown that BRCA1 interacts in vitro and in vivo with hRad50, which forms a complex with hMre11 and p95/nibrin. Upon irradiation, BRCA1 was detected in discrete foci in the nucleus, which colocalize w...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-07, Vol.285 (5428), p.747-750
Hauptverfasser:	QING ZHONG, CHEN, C.-F, SHANG LI, YUMAY CHEN, WANG, C.-C, JUN XIAO, CHEN, P.-L, SHARP, Z. D, LEE, W.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases Biological and medical sciences BRCA1 Protein - metabolism Breast cancer Cell Cycle Proteins - metabolism Cell Nucleus - metabolism Cell physiology Cell Survival Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells Deoxyribonucleic acid DNA DNA Damage DNA Repair Enzymes DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Gamma Rays Genes Genes, BRCA1 Humans Methyl Methanesulfonate - pharmacology Molecular and cellular biology MRE11 Homologue Protein Mutagens - pharmacology Mutation Nuclear Proteins Proteins Rad51 Recombinase Radiation Recombination, Genetic Transfection Tumor Cells, Cultured Tumors
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