Structural basis for activation of the titin kinase domain during myofibrillogenesis

The giant muscle protein titin (connectin) is essential in the temporal and spatial control of the assembly of the highly ordered sarcomeres (contractile units) of striated muscle. Here we present the crystal structure of titin's only catalytic domain, an autoregulated serine kinase (titin kina...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1998-10, Vol.395 (6705), p.863-869
Hauptverfasser:	Wilmanns, Matthias, Gautel, Mathias, Mayans, Olga, van der Ven, Peter F. M, Wilm, Matthias, Mues, Alexander, Young, Paul, Fürst, Dieter O
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Catalytic Domain Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Connectin Crystallography Crystallography, X-Ray Enzyme Activation Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Humans Models, Molecular Molecular and cellular biology Molecular Sequence Data multidisciplinary Muscle Proteins - antagonists & inhibitors Muscle Proteins - chemistry Muscle Proteins - metabolism Muscle, Skeletal - cytology Muscle, Skeletal - enzymology Muscular system Myofibrils - enzymology Phosphorylation Protein Conformation Protein Kinase Inhibitors Protein Kinases - chemistry Protein Kinases - metabolism Proteins Recombinant Proteins - chemistry Science Science (multidisciplinary) Sequence Homology, Amino Acid Substrate Specificity Tyrosine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!