Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns
Inositol 1,4,5-trisphosphate (IP3) is a second messenger that elicits complex spatiotemporal patterns of calcium ion (Ca2+) mobilization and has essential roles in the regulation of many cellular functions. In Madin-Darby canine kidney epithelial cells, green fluorescent protein-tagged pleckstrin ho...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1999-05, Vol.284 (5419), p.1527-1530 |
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| creator | HIROSE, K KADOWAKI, S TANABE, M TAKESHIMA, H IINO, M |
| description | Inositol 1,4,5-trisphosphate (IP3) is a second messenger that elicits complex spatiotemporal patterns of calcium ion (Ca2+) mobilization and has essential roles in the regulation of many cellular functions. In Madin-Darby canine kidney epithelial cells, green fluorescent protein-tagged pleckstrin homology domain translocated from the plasma membrane to the cytoplasm in response to increased concentration of IP3. The detection of translocation enabled monitoring of IP3 concentration changes within single cells and revealed spatiotemporal dynamics in the concentration of IP3 synchronous with Ca2+ oscillations and intracellular and intercellular IP3 waves that accompanied Ca2+ waves. Such changes in IP3 concentration may be fundamental to Ca2+ signaling. |
| doi_str_mv | 10.1126/science.284.5419.1527 |
| format | Article |
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In Madin-Darby canine kidney epithelial cells, green fluorescent protein-tagged pleckstrin homology domain translocated from the plasma membrane to the cytoplasm in response to increased concentration of IP3. The detection of translocation enabled monitoring of IP3 concentration changes within single cells and revealed spatiotemporal dynamics in the concentration of IP3 synchronous with Ca2+ oscillations and intracellular and intercellular IP3 waves that accompanied Ca2+ waves. Such changes in IP3 concentration may be fundamental to Ca2+ signaling.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.284.5419.1527</identifier><identifier>PMID: 10348740</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Adenosine Triphosphate - pharmacology ; Animals ; Biological and medical sciences ; Calcium ; Calcium - metabolism ; Calcium Signaling ; Cell Line ; Cell Membrane - metabolism ; Cell Nucleus - metabolism ; Cell physiology ; Cells ; Cytoplasm - metabolism ; Dogs ; Fundamental and applied biological sciences. Psychology ; Green Fluorescent Proteins ; Inositol 1,4,5-Trisphosphate - metabolism ; Inositol Phosphates - metabolism ; Ions ; Isoenzymes - chemistry ; Isoenzymes - metabolism ; Kidneys ; Ligands ; Luminescent Proteins ; Microscopy, Confocal ; Molecular and cellular biology ; Phosphatidylinositol 4,5-Diphosphate - metabolism ; Phospholipase C delta ; Proteins ; Recombinant Fusion Proteins - metabolism ; Signal transduction ; Time Factors ; Type C Phospholipases - chemistry ; Type C Phospholipases - metabolism</subject><ispartof>Science (American Association for the Advancement of Science), 1999-05, Vol.284 (5419), p.1527-1530</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Association for the Advancement of Science May 28, 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1834393$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10348740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIROSE, K</creatorcontrib><creatorcontrib>KADOWAKI, S</creatorcontrib><creatorcontrib>TANABE, M</creatorcontrib><creatorcontrib>TAKESHIMA, H</creatorcontrib><creatorcontrib>IINO, M</creatorcontrib><title>Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Inositol 1,4,5-trisphosphate (IP3) is a second messenger that elicits complex spatiotemporal patterns of calcium ion (Ca2+) mobilization and has essential roles in the regulation of many cellular functions. In Madin-Darby canine kidney epithelial cells, green fluorescent protein-tagged pleckstrin homology domain translocated from the plasma membrane to the cytoplasm in response to increased concentration of IP3. The detection of translocation enabled monitoring of IP3 concentration changes within single cells and revealed spatiotemporal dynamics in the concentration of IP3 synchronous with Ca2+ oscillations and intracellular and intercellular IP3 waves that accompanied Ca2+ waves. Such changes in IP3 concentration may be fundamental to Ca2+ signaling.</description><subject>Adenosine Triphosphate - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium Signaling</subject><subject>Cell Line</subject><subject>Cell Membrane - metabolism</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell physiology</subject><subject>Cells</subject><subject>Cytoplasm - metabolism</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Green Fluorescent Proteins</subject><subject>Inositol 1,4,5-Trisphosphate - metabolism</subject><subject>Inositol Phosphates - metabolism</subject><subject>Ions</subject><subject>Isoenzymes - chemistry</subject><subject>Isoenzymes - metabolism</subject><subject>Kidneys</subject><subject>Ligands</subject><subject>Luminescent Proteins</subject><subject>Microscopy, Confocal</subject><subject>Molecular and cellular biology</subject><subject>Phosphatidylinositol 4,5-Diphosphate - metabolism</subject><subject>Phospholipase C delta</subject><subject>Proteins</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>Signal transduction</subject><subject>Time Factors</subject><subject>Type C Phospholipases - chemistry</subject><subject>Type C Phospholipases - metabolism</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90E1rFTEUBuAgir2t_QmWUIou7Nzme5JludQPKLhQ18OZTC5NySRjkoHWX2_EW4QuXORk8T68IQeht5RsKWXqqljvonVbpsVWCmq2VLL-BdpQYmRnGOEv0YYQrjpNenmEjku5J6Rlhr9GR5RwoXtBNsh_W6D6VN28pAwBT48RZm8LTnvsYyq-poDppbiUXc2-LHepHagO1zbxGieXg3cF2zQvwT3gHbAPeE6jD_7Xn-KIW391OZY36NUeQnGnh_sE_fh48333ubv9-unL7vq2u2NS105ZOtlRcQVOgAUqRjOBUNPktDKUtFhLTqUwBEbHrJR2L6SwlmsglhnBT9D7v71LTj9XV-ow-2JdCBBdWsvQC95LZgxp8t1_pTJ9e5OrBs-fwfu05th-MTDKpaa6Zw2dHdA6zm4aluxnyI_D064buDgAKBbCPkO0vvxzmgtuOP8N_JWP-w</recordid><startdate>19990528</startdate><enddate>19990528</enddate><creator>HIROSE, K</creator><creator>KADOWAKI, S</creator><creator>TANABE, M</creator><creator>TAKESHIMA, H</creator><creator>IINO, M</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990528</creationdate><title>Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns</title><author>HIROSE, K ; 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Psychology</topic><topic>Green Fluorescent Proteins</topic><topic>Inositol 1,4,5-Trisphosphate - metabolism</topic><topic>Inositol Phosphates - metabolism</topic><topic>Ions</topic><topic>Isoenzymes - chemistry</topic><topic>Isoenzymes - metabolism</topic><topic>Kidneys</topic><topic>Ligands</topic><topic>Luminescent Proteins</topic><topic>Microscopy, Confocal</topic><topic>Molecular and cellular biology</topic><topic>Phosphatidylinositol 4,5-Diphosphate - metabolism</topic><topic>Phospholipase C delta</topic><topic>Proteins</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>Signal transduction</topic><topic>Time Factors</topic><topic>Type C Phospholipases - chemistry</topic><topic>Type C Phospholipases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIROSE, K</creatorcontrib><creatorcontrib>KADOWAKI, S</creatorcontrib><creatorcontrib>TANABE, M</creatorcontrib><creatorcontrib>TAKESHIMA, 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Science)</jtitle><addtitle>Science</addtitle><date>1999-05-28</date><risdate>1999</risdate><volume>284</volume><issue>5419</issue><spage>1527</spage><epage>1530</epage><pages>1527-1530</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Inositol 1,4,5-trisphosphate (IP3) is a second messenger that elicits complex spatiotemporal patterns of calcium ion (Ca2+) mobilization and has essential roles in the regulation of many cellular functions. In Madin-Darby canine kidney epithelial cells, green fluorescent protein-tagged pleckstrin homology domain translocated from the plasma membrane to the cytoplasm in response to increased concentration of IP3. The detection of translocation enabled monitoring of IP3 concentration changes within single cells and revealed spatiotemporal dynamics in the concentration of IP3 synchronous with Ca2+ oscillations and intracellular and intercellular IP3 waves that accompanied Ca2+ waves. Such changes in IP3 concentration may be fundamental to Ca2+ signaling.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>10348740</pmid><doi>10.1126/science.284.5419.1527</doi><tpages>4</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 1999-05, Vol.284 (5419), p.1527-1530 |
| issn | 0036-8075 1095-9203 |
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| subjects | Adenosine Triphosphate - pharmacology Animals Biological and medical sciences Calcium Calcium - metabolism Calcium Signaling Cell Line Cell Membrane - metabolism Cell Nucleus - metabolism Cell physiology Cells Cytoplasm - metabolism Dogs Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins Inositol 1,4,5-Trisphosphate - metabolism Inositol Phosphates - metabolism Ions Isoenzymes - chemistry Isoenzymes - metabolism Kidneys Ligands Luminescent Proteins Microscopy, Confocal Molecular and cellular biology Phosphatidylinositol 4,5-Diphosphate - metabolism Phospholipase C delta Proteins Recombinant Fusion Proteins - metabolism Signal transduction Time Factors Type C Phospholipases - chemistry Type C Phospholipases - metabolism |
| title | Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns |
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