Single Molecule Force Spectroscopy on Polysaccharides by Atomic Force Microscopy

Recent developments in piconewton instrumentation allow the manipulation of single molecules and measurements of intermolecular as well as intramolecular forces. Dextran filaments linked to a gold surface were probed with the atomic force microscope tip by vertical stretching. At low forces the defo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-02, Vol.275 (5304), p.1295-1297
Hauptverfasser:	Rief, Matthias, Oesterhelt, Filipp, Heymann, Berthold, Gaub, Hermann E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Atomic force microscopy Atomic spectroscopy Biological and medical sciences Cantilevers Carbohydrates Chemical bonding Dextrans Drug interactions Elasticity Fundamental and applied biological sciences. Psychology Holosides Laboratory Equipment Molecular spectroscopy Molecules Monomers Observations Other biological molecules Physics Polymers Polysaccharides Scientific Concepts Spectroscopy
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