Regulation of Maternal Behavior and Offspring Growth by Paternally Expressed Peg3

Imprinted genes display parent-of-origin- dependent monoallelic expression that apparently regulates complex mammalian traits, including growth and behavior. The Peg3 gene is expressed in embryos and the adult brain from the paternal allele only. A mutation in the Peg3 gene resulted in growth retard...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-04, Vol.284 (5412), p.330-333
Hauptverfasser:	L.-L. Li, Keverne, E. B., Aparicio, S. A., Ishino, F., Barton, S. C., Surani, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Anatomy Animal parental behavior Animals Animals, Newborn Behavior Biological and medical sciences Birth Brain Brain - metabolism Child Health Classical genetics, quantitative genetics, hybrids Coding Control Groups Crosses, Genetic Embryos Exons Female Female animals Females Fundamental and applied biological sciences. Psychology Gene Expression Gene Targeting Genetic loci Genetic mutation Genetics Genetics of eukaryotes. Biological and molecular evolution Genomes Genomic Imprinting Growth Hypothalamus - cytology Hypothalamus - metabolism Kruppel-Like Transcription Factors Lactation Male Mammals Maternal Behavior Mice Mothers Mutation Nervous system Neural Pathways Neurons Neurons - metabolism Oxytocin - metabolism Parental behavior in animals Pegademase Phenotype Physical growth Pregnancy Protein Kinases Proteins - genetics Proteins - physiology Pups Transcription Factors Vertebrata Weight Gain
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