Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry

Nonpeptide agonists of each of the five somatostatin receptors were identified in combinatorial libraries constructed on the basis of molecular modeling of known peptide agonists. In vitro experiments using these selective compounds demonstrated the role of the somatostatin subtype-2 receptor in inh...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-10, Vol.282 (5389), p.737-740
Hauptverfasser:	Rohrer, Susan P., Birzin, Elizabeth T., Mosley, Ralph T., Berk, Scott C., Hutchins, Steven M., Shen, Dong-Ming, Xiong, Yusheng, Hayes, Edward C., Parmar, Rupa M., Foor, Forrest, Mitra, Sudha W., Degrado, Sylvia J., Shu, Min, Klopp, John M., Cai, Sheng-Jian, Blake, Allan, Wanda W. S. Chan, Pasternak, Alex, Yang, Lihu, Patchett, Arthur A., Smith, Roy G., Chapman, Kevin T., Schaeffer, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Amides - metabolism Amides - pharmacology Amino Acid Sequence Anatomy Animals Biological and medical sciences Cell Line Cells, Cultured Chemistry Combinatorial chemistry Cricetinae Drug Design Endocrinology Functional groups General pharmacology Glucagon - metabolism Growth Hormone - metabolism Growth hormones Hormones Inhibition Insulin Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism L cells Libraries Ligands Medical sciences Membrane Proteins Mice Models, Chemical Molecular Sequence Data Organic Chemistry Pancreas Peptides Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Pituitary gland Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Rats Receptors Receptors, Somatostatin - agonists Receptors, Somatostatin - physiology Rodents Secretion Somatostatin Somatostatin receptors
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