A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer

The mid/hindbrain (MHB) junction can act as an organizer to direct the development of the midbrain and anterior hindbrain. In mice, Otx2 is expressed in the forebrain and midbrain and Gbx2 is expressed in the anterior hindbrain, with a shared border at the level of the MHB organizer. Here we show th...

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Veröffentlicht in:	Nature (London) 1999-09, Vol.401 (6749), p.161-164
Hauptverfasser:	Joyner, Alexandra L, Millet, Sandrine, Campbell, Kenneth, Epstein, Douglas J, Losos, Kasia, Harris, Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Embryology: invertebrates and vertebrates. Teratology Embryos Fundamental and applied biological sciences. Psychology Genes Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humanities and Social Sciences letter Mesencephalon - embryology Mice Mice, Transgenic Molecular embryology multidisciplinary Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Otx Transcription Factors Proto-Oncogene Proteins - genetics Rhombencephalon - embryology Rodents Science Science (multidisciplinary) Trans-Activators - genetics Trans-Activators - physiology Wnt Proteins Zebrafish Proteins
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