A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation
During T cell activation, the engagement of costimulatory molecules is often crucial to the development of an effective immune response, but the mechanism by which this is achieved is not known. Here, it is shown that beads attached to the surface of a T cell translocate toward the interface shortly...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1998-12, Vol.282 (5397), p.2266-2269 |
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| description | During T cell activation, the engagement of costimulatory molecules is often crucial to the development of an effective immune response, but the mechanism by which this is achieved is not known. Here, it is shown that beads attached to the surface of a T cell translocate toward the interface shortly after the start of T cell activation. This movement appears to depend on myosin motor proteins and requires the engagement of the major costimulatory receptor pairs, B7-CD28 and ICAM-1-LFA-1. This suggests that the engagement of costimulatory receptors triggers an active accumulation of molecules at the interface of the T cell and the antigen-presenting cell, which then increases the overall amplitude and duration of T cell signaling. |
| doi_str_mv | 10.1126/science.282.5397.2266 |
| format | Article |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1998-12, Vol.282 (5397), p.2266-2269 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743734705 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Antigen Presentation Antigen-Presenting Cells - immunology Antigens, CD - metabolism B cell lymphoma B7-2 Antigen Biological and medical sciences Biotinylation Calcium Calcium - metabolism CD28 Antigens - metabolism CHO Cells Cricetinae Cytoskeleton Cytoskeleton - physiology Drug interactions Fundamental and applied biological sciences. Psychology Fundamental immunology Immune system Immunity (Disease) Immunobiology Intercellular Adhesion Molecule-1 - metabolism Lymphocyte Activation Lymphocyte Function-Associated Antigen-1 - metabolism Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Membrane Glycoproteins - metabolism Mice Microfilaments Microscopy Microspheres Molecular biology Molecular Motor Proteins - physiology Molecules Myosins - physiology Phosphatidylinositol 3-Kinases - metabolism Proteins Receptors Receptors, Antigen, T-Cell - immunology Signal Transduction T cell antigen receptors T cells T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - ultrastructure Tumor Cells, Cultured |
| title | A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation |
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