Recruitment of the Auditory Cortex in Congenitally Deaf Cats by Long-Term Cochlear Electrostimulation
In congenitally deaf cats, the central auditory system is deprived of acoustic input because of degeneration of the organ of Corti before the onset of hearing. Primary auditory afferents survive and can be stimulated electrically. By means of an intracochlear implant and an accompanying sound proces...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1999-09, Vol.285 (5434), p.1729-1733 |
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| creator | Klinke, Rainer Kral, Andrej Heid, Silvia Tillein, Jochen Hartmann, Rainer |
| description | In congenitally deaf cats, the central auditory system is deprived of acoustic input because of degeneration of the organ of Corti before the onset of hearing. Primary auditory afferents survive and can be stimulated electrically. By means of an intracochlear implant and an accompanying sound processor, congenitally deaf kittens were exposed to sounds and conditioned to respond to tones. After months of exposure to meaningful stimuli, the cortical activity in chronically implanted cats produced field potentials of higher amplitudes, expanded in area, developed long latency responses indicative of intracortical information processing, and showed more synaptic efficacy than in naïve, unstimulated deaf cats. The activity established by auditory experience resembles activity in hearing animals. |
| doi_str_mv | 10.1126/science.285.5434.1729 |
| format | Article |
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Primary auditory afferents survive and can be stimulated electrically. By means of an intracochlear implant and an accompanying sound processor, congenitally deaf kittens were exposed to sounds and conditioned to respond to tones. After months of exposure to meaningful stimuli, the cortical activity in chronically implanted cats produced field potentials of higher amplitudes, expanded in area, developed long latency responses indicative of intracortical information processing, and showed more synaptic efficacy than in naïve, unstimulated deaf cats. The activity established by auditory experience resembles activity in hearing animals.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.285.5434.1729</identifier><identifier>PMID: 10481008</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Acoustic Stimulation ; Anatomy ; Animals ; Assistive Technology ; Auditory cortex ; Auditory Cortex - physiology ; Auditory pathway ; Auditory pathways ; Auditory Pathways - physiology ; Auditory perception ; Biological and medical sciences ; Cats ; Cats as laboratory animals ; Cochlea - physiology ; Cochlear implantation ; Cochlear Implants ; Coding ; Conditioning (Psychology) ; Deafness ; Deafness - congenital ; Deafness - physiopathology ; Deafness - therapy ; Domestic cats ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Ears & hearing ; Electric fields ; Electric Stimulation ; Electrical stimulation ; Electrodes ; Evoked Potentials, Auditory ; Experimental Groups ; Experiments ; Feedback (Response) ; Hearing ; Hearing aids ; Information Processing ; Laboratory animals ; Medical research ; Medical sciences ; Non tumoral diseases ; Otorhinolaryngology. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1999-09, Vol.285 (5434), p.1729-1733 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743734257 |
| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Acoustic Stimulation Anatomy Animals Assistive Technology Auditory cortex Auditory Cortex - physiology Auditory pathway Auditory pathways Auditory Pathways - physiology Auditory perception Biological and medical sciences Cats Cats as laboratory animals Cochlea - physiology Cochlear implantation Cochlear Implants Coding Conditioning (Psychology) Deafness Deafness - congenital Deafness - physiopathology Deafness - therapy Domestic cats Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ears & hearing Electric fields Electric Stimulation Electrical stimulation Electrodes Evoked Potentials, Auditory Experimental Groups Experiments Feedback (Response) Hearing Hearing aids Information Processing Laboratory animals Medical research Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Physiological aspects Sensory Experience Sound Stimuli Synapses - physiology Time Factors |
| title | Recruitment of the Auditory Cortex in Congenitally Deaf Cats by Long-Term Cochlear Electrostimulation |
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