Postsynaptic Membrane Fusion and Long-Term Potentiation

The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP....

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-01, Vol.279 (5349), p.399-403
Hauptverfasser:	Lledo, Pierre-Marie, Zhang, Xiangyang, Südhof, Thomas C., Malenka, Robert C., Nicoll, Roger A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anatomy Animals Biochemistry Biological and medical sciences Botulinum toxins Botulinum Toxins - pharmacology Carrier Proteins - metabolism Carrier Proteins - pharmacology Cells Cellular biology Central nervous system Electrodes Electrophysiology Ethylmaleimide - pharmacology Excitatory Postsynaptic Potentials Exocytosis Fundamental and applied biological sciences. Psychology Guinea Pigs Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Long term potentiation Long-Term Potentiation - drug effects Membrane Fusion Membrane Proteins - metabolism Membrane Proteins - pharmacology Membranes Molecular Sequence Data N-Ethylmaleimide-Sensitive Proteins Neural circuitry Neurons P branes Patch-Clamp Techniques Peptides - pharmacology Physiological aspects Pipettes Pyramidal cells Pyramidal Cells - physiology Receptors Receptors, N-Methyl-D-Aspartate - physiology Recombinant Proteins - pharmacology Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins Synapses Synaptic Membranes - physiology Synaptic Transmission T tests Vertebrates: nervous system and sense organs Vesicular Transport Proteins
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