Notch Signaling: Cell Fate Control and Signal Integration in Development

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, N...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-04, Vol.284 (5415), p.770-776
Hauptverfasser:	Artavanis-Tsakonas, Spyros, Rand, Matthew D., Lake, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis Cell Communication Cell Division Cell lines Cell Nucleus - metabolism Cell regulation Cell transformation Cells Cellular biology Cellular control mechanisms Cultured cells Developmental Programs Developmental Stages Drosophila Genetic mutation Humans Individualized Instruction Intracellular Signaling Peptides and Proteins Ligands Membrane Proteins - physiology Neurons Notch receptors Receptors Receptors, Cell Surface - physiology Receptors, Notch Reviews Signal Transduction Stem cells Transcription, Genetic
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