Inhibition of Toxic Epidermal Necrolysis by Blockade of CD95 with Human Intravenous Immunoglobulin

Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found to express lytically active...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-10, Vol.282 (5388), p.490-493
Hauptverfasser:	Viard, Isabelle, Wehrli, Philippe, Bullani, Roberto, Schneider, Pascal, Holler, Nils, Salomon, Denis, Hunziker, Thomas, Saurat, Jean-Hilaire, Tschopp, Jürg, French, Lars E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Albumins Antibodies Antibodies, Blocking - immunology Antibodies, Blocking - therapeutic use Apoptosis Biological and medical sciences Care and treatment Cell death Child Control Groups Dermis - pathology Disease Progression Drug Use Epidermis - pathology Fas Ligand Protein fas Receptor - immunology fas Receptor - physiology Female Health aspects Humans Immune system Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Immunology Inhibition Jurkat Cells Keratinocytes Keratinocytes - metabolism Keratinocytes - pathology Ligands Male Medical research Medical sciences Membrane Glycoproteins - metabolism Middle Aged Patients Pharmacology Pharmacology. Drug treatments Pilot Projects Skin Skin, nail, hair, dermoskeleton Stevens-Johnson Syndrome - pathology Stevens-Johnson Syndrome - therapy T lymphocytes Toxic epidermal necrolysis Wigs
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