Enantioselective Synthesis of Chiral Tetrahydroisoquinolines by Iridium-Catalyzed Asymmetric Hydrogenation of Enamines

Chiral iridium complexes based on spiro phosphoramidite ligands are demonstrated to be highly efficient catalysts for the asymmetric hydrogenation of unfunctionalized enamines with an exocyclic double bond. In combination with excess iodine or potassium iodide and under hydrogen pressure, the comple...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Advanced synthesis & catalysis 2009-12, Vol.351 (18), p.3243-3250
Hauptverfasser:	Yan, Pu-Cha, Xie, Jian-Hua, Hou, Guo-Hua, Wang, Li-Xin, Zhou, Qi-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric synthesis enamines hydrogenation iridium phosphoramidites tetrahydroisoquinolines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!