$Impaired Immunoproteasome Assembly and Immune Responses in PA28$^{-/-}$ Mice$

Impaired Immunoproteasome Assembly and Immune Responses in PA28$^{-/-}$ Mice

In vitro PA28 binds and activates proteasomes. It is shown here that mice with a disrupted PA28b gene lack PA28a and PA28b polypeptides, demonstrating that PA28 functions as a hetero-oligomer in vivo. Processing of antigenic epitopes derived from exogenous or endogenous antigens is altered in PA28$^...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-12, Vol.286 (5447), p.2162-2165
Hauptverfasser:	Preckel, Tobias, Fung-Leung, Wai-Ping, Cai, Zeling, Vitiello, Antonella, Salter-Cid, Luisa, Winqvist, Ola, Wolfe, Tom G., von Herrath, Matthias, Angulo, Ana, Ghazal, Peter, Lee, Jiing-Dwan, Fourie, Anne M., Wu, Ying, Pang, Jesse, Ngo, Karen, Peterson, Per A., Früh, Klaus, Yang, Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation Antigens Autoantigens Biological and medical sciences Blasts Cellular biology Communicable Diseases Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - metabolism Enzyme Activators - metabolism Epitopes Epitopes, T-Lymphocyte - immunology Feedback (Response) Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genes H-Y Antigen - immunology Herpesviridae Infections - immunology Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Immunobiology Immunology Immunoprecipitation Infections Interferons - pharmacology Lymphocytic Choriomeningitis - immunology Lymphocytic choriomeningitis virus - immunology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Male animals Males Mice Molecules Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Muromegalovirus - immunology Ovalbumin - immunology Peptide Fragments - immunology Peptides Proteasome Endopeptidase Complex Proteins - genetics Proteins - metabolism Rodents Splenocytes T lymphocytes T-Lymphocytes, Cytotoxic - immunology
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