Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1
Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skin revealed that the VEGF-induced blood vessels were leaky, whereas those induced by Ang1 were nonleaky. Moreov...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1999-12, Vol.286 (5449), p.2511-2514 |
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| creator | Thurston, G. Suri, C. Smith, K. McClain, J. Sato, T. N. Yancopoulos, G. D. McDonald, D. M. |
| description | Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skin revealed that the VEGF-induced blood vessels were leaky, whereas those induced by Ang1 were nonleaky. Moreover, vessels in Ang1-overexpressing mice were resistant to leaks caused by inflammatory agents. Coexpression of Ang1 and VEGF had an additive effect on angiogenesis but resulted in leakage-resistant vessels typical of Ang1. Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels. |
| doi_str_mv | 10.1126/science.286.5449.2511 |
| format | Article |
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Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.286.5449.2511</identifier><identifier>PMID: 10617467</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Analysis ; Angiogenesis ; Angiopoietin-1 ; Animals ; Arterioles - anatomy & histology ; Arterioles - physiology ; Basement membrane ; Binding Sites ; Biological and medical sciences ; Blood coagulation factors ; Blood vessels ; Capillaries ; Capillaries - anatomy & histology ; Capillaries - physiology ; Capillary Permeability ; Cellular biology ; Classical genetics, quantitative genetics, hybrids ; Ear ; Ears ; Endothelial Growth Factors - genetics ; Endothelial Growth Factors - physiology ; Endothelium, Vascular - metabolism ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Inflammation - chemically induced ; Inflammation Mediators - pharmacology ; Lymphokines - genetics ; Lymphokines - physiology ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - physiology ; Mice ; Mice, Transgenic ; Microcirculation - anatomy & histology ; Microcirculation - physiology ; Mustard Plant ; Mustards ; Neovascularization, Physiologic ; Observations ; Plant Extracts - pharmacology ; Plant Lectins ; Plant Oils ; Plants, Medicinal ; Platelet Activating Factor - pharmacology ; Ricin - metabolism ; Rodents ; Serotonin - pharmacology ; Skin ; Skin - blood supply ; Skin - metabolism ; Transgenic animals ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Venules ; Venules - anatomy & histology ; Venules - physiology ; Vertebrata</subject><ispartof>Science (American Association for the Advancement of Science), 1999-12, Vol.286 (5449), p.2511-2514</ispartof><rights>Copyright 1999 American Association for the Advancement of Science</rights><rights>2000 INIST-CNRS</rights><rights>COPYRIGHT 1999 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1999 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Dec 24, 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c786t-7e93f6cee4bd5431d7dfff9a59a3b5c4164afdf72835b26f12b16f7226e1c0b83</citedby><cites>FETCH-LOGICAL-c786t-7e93f6cee4bd5431d7dfff9a59a3b5c4164afdf72835b26f12b16f7226e1c0b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2899884$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2899884$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1236392$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10617467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thurston, G.</creatorcontrib><creatorcontrib>Suri, C.</creatorcontrib><creatorcontrib>Smith, K.</creatorcontrib><creatorcontrib>McClain, J.</creatorcontrib><creatorcontrib>Sato, T. N.</creatorcontrib><creatorcontrib>Yancopoulos, G. D.</creatorcontrib><creatorcontrib>McDonald, D. M.</creatorcontrib><title>Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skin revealed that the VEGF-induced blood vessels were leaky, whereas those induced by Ang1 were nonleaky. Moreover, vessels in Ang1-overexpressing mice were resistant to leaks caused by inflammatory agents. Coexpression of Ang1 and VEGF had an additive effect on angiogenesis but resulted in leakage-resistant vessels typical of Ang1. Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels.</description><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Angiopoietin-1</subject><subject>Animals</subject><subject>Arterioles - anatomy & histology</subject><subject>Arterioles - physiology</subject><subject>Basement membrane</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Blood coagulation factors</subject><subject>Blood vessels</subject><subject>Capillaries</subject><subject>Capillaries - anatomy & histology</subject><subject>Capillaries - physiology</subject><subject>Capillary Permeability</subject><subject>Cellular biology</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Ear</subject><subject>Ears</subject><subject>Endothelial Growth Factors - genetics</subject><subject>Endothelial Growth Factors - physiology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. 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N. ; Yancopoulos, G. D. ; McDonald, D. 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N.</au><au>Yancopoulos, G. D.</au><au>McDonald, D. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1999-12-24</date><risdate>1999</risdate><volume>286</volume><issue>5449</issue><spage>2511</spage><epage>2514</epage><pages>2511-2514</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skin revealed that the VEGF-induced blood vessels were leaky, whereas those induced by Ang1 were nonleaky. Moreover, vessels in Ang1-overexpressing mice were resistant to leaks caused by inflammatory agents. Coexpression of Ang1 and VEGF had an additive effect on angiogenesis but resulted in leakage-resistant vessels typical of Ang1. Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>10617467</pmid><doi>10.1126/science.286.5449.2511</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1999-12, Vol.286 (5449), p.2511-2514 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743682156 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Analysis Angiogenesis Angiopoietin-1 Animals Arterioles - anatomy & histology Arterioles - physiology Basement membrane Binding Sites Biological and medical sciences Blood coagulation factors Blood vessels Capillaries Capillaries - anatomy & histology Capillaries - physiology Capillary Permeability Cellular biology Classical genetics, quantitative genetics, hybrids Ear Ears Endothelial Growth Factors - genetics Endothelial Growth Factors - physiology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Inflammation - chemically induced Inflammation Mediators - pharmacology Lymphokines - genetics Lymphokines - physiology Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Mice Mice, Transgenic Microcirculation - anatomy & histology Microcirculation - physiology Mustard Plant Mustards Neovascularization, Physiologic Observations Plant Extracts - pharmacology Plant Lectins Plant Oils Plants, Medicinal Platelet Activating Factor - pharmacology Ricin - metabolism Rodents Serotonin - pharmacology Skin Skin - blood supply Skin - metabolism Transgenic animals Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Venules Venules - anatomy & histology Venules - physiology Vertebrata |
| title | Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T06%3A29%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Leakage-Resistant%20Blood%20Vessels%20in%20Mice%20Transgenically%20Overexpressing%20Angiopoietin-1&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Thurston,%20G.&rft.date=1999-12-24&rft.volume=286&rft.issue=5449&rft.spage=2511&rft.epage=2514&rft.pages=2511-2514&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.286.5449.2511&rft_dat=%3Cgale_proqu%3EA58617042%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213581348&rft_id=info:pmid/10617467&rft_galeid=A58617042&rft_jstor_id=2899884&rfr_iscdi=true |