Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

Urotensin-II (U-II) is a vasoactive ‘somatostatin-like’ cyclic peptide which was originally isolated from fish spinal cords 1 , 2 , and which has recently been cloned from man 3 . Here we describe the identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 (refs 4 , 5 )...

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Veröffentlicht in:	Nature (London) 1999-09, Vol.401 (6750), p.282-286
Hauptverfasser:	Ames, Robert S., Sarau, Henry M., Chambers, Johathan K., Willette, Robert N., Aiyar, Nambi V., Romanic, Anne M., Louden, Calvert S., Foley, James J., Sauermelch, Charles F., Coatney, Robert W., Ao, Zhaohui, Disa, Jyoti, Holmes, Stephen D., Stadel, Jeffrey M., Martin, John D., Liu, Wu-Schyong, Glover, George I., Wilson, Shelagh, McNulty, Dean E., Ellis, Catherine E., Elshourbagy, Nabil A., Shabon, Usman, Trill, John J., Hay, Douglas W. P., Ohlstein, Eliot H., Bergsma, Derk J., Douglas, Stephen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences Brain Calcium - metabolism Cell Line Central nervous system Cloning, Molecular DNA, Complementary Fundamental and applied biological sciences. Psychology Genes. Genome Genomics GTP-Binding Proteins - agonists GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Hormones and neuropeptides. Regulation Humanities and Social Sciences Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis letter Macaca fascicularis Male Molecular and cellular biology Molecular genetics Molecular Sequence Data multidisciplinary Peptides Proteins Rats Rats, Sprague-Dawley Receptors, Cell Surface - agonists Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Rodents Science Science (multidisciplinary) Sequence Homology, Amino Acid Tissue Distribution Urotensins - metabolism Urotensins - pharmacology Vasoconstrictor Agents - metabolism Vasoconstrictor Agents - pharmacology Vertebrates: endocrinology
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