Functional alterations of alveolar macrophages subjected to smoke exposure and antioxidant lazaroids

Acute inhalation of diesel fuel-polycarbonate plastic (DFPP) smoke causes severe lung injury, leading to acute respiratory distress syndrome (ARDS) and death. It has been reported that the initiation of acute lung injury is associated with the activation of pulmonary alveolar macrophages (PAM). To f...

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Veröffentlicht in:	Toxicology and industrial health 1999-08, Vol.15 (5), p.464-469
Hauptverfasser:	Wang, Shengjun, Lantz, R. Clark, Vermeulen, Mary W., Chen, Guan Jie, Breceda, Veronica, Robledo, Raymond F., Hays, Allison M., Young, Scott, Witten, Mark L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols - pharmacology Animals Antioxidants - pharmacology Bronchoalveolar Lavage Fluid - cytology Cell Count - drug effects Cells, Cultured Culture Media, Conditioned - chemistry Female Gasoline - toxicity Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Polycarboxylate Cement - toxicity Rabbits Respiratory Burst - drug effects RNA, Messenger - metabolism Smoke - adverse effects Smoke Inhalation Injury - metabolism Smoke Inhalation Injury - prevention & control Specific Pathogen-Free Organisms Steroids - pharmacology Superoxides - metabolism tumor necrosis factor-^a Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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