Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

The transforming proteins of acute promyelocytic leukaemias (APL) are fusions of the promyelocytic leukaemia (PML) and the promyelocytic leukaemia zinc-finger (PLZF) proteins with retinoic acid receptor-α (RARα),. These proteins retain the RARα DNA- and retinoic acid (RA)-binding domains, and their...

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Veröffentlicht in:	Nature (London) 1998-02, Vol.391 (6669), p.815-818
Hauptverfasser:	Pelicci, Pier Giuseppe, Grignani, Francesco, De Matteis, Silvia, Nervi, Clara, Tomassoni, Lucia, Gelmetti, Vania, Cioce, Mario, Fanelli, Mirco, Ruthardt, Marthin, Ferrara, Fabiana F, Zamir, Iris, Seiser, Christian, Grignani, Fausto, Lazar, Mitchell A, Minucci, Saverio
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Biological effects Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cloning, Molecular Deoxyribonucleic acid DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Genes Genetics Histone Deacetylase Inhibitors Histone Deacetylases - genetics Histone Deacetylases - physiology Hydroxamic Acids - pharmacology Leukemia Leukemia, Promyelocytic, Acute - enzymology Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - metabolism Medical research Molecular and cellular biology Mutagenesis Neoplasm Proteins - genetics Neoplasm Proteins - physiology Nuclear Proteins - genetics Nuclear Proteins - physiology Nuclear Receptor Co-Repressor 1 Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - physiology Protein Binding Proteins Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - physiology Repressor Proteins - genetics Repressor Proteins - physiology Retinoic Acid Receptor alpha Transcription Factors - genetics Transcription Factors - physiology Tretinoin - pharmacology Tumor Suppressor Proteins
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