Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium d...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1998-10, Vol.282 (5388), p.480-483 |
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| creator | Randolph, Gwendalyn J. Beaulieu, Sylvie Lebecque, Serge Steinman, Ralph M. Muller, William A. |
| description | Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen. These nascent dendritic cells migrated across the endothelium in the ablumenal-to-lumenal direction, as would occur during entry into lymphatics. Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration. |
| doi_str_mv | 10.1126/science.282.5388.480 |
| format | Article |
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Therefore, monocytes have two potential fates associated with distinct patterns of migration.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.282.5388.480</identifier><identifier>PMID: 9774276</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Antigen presenting cells ; Antigens, CD - analysis ; Biological and medical sciences ; Carrier Proteins - analysis ; Cell Count ; Cell Differentiation ; Cell Movement ; Cells ; Cells, Cultured ; Cellular biology ; Collagen ; Collagens ; Cultured cells ; Dendritic cells ; Dendritic Cells - cytology ; Dendritic Cells - immunology ; Dendritic Cells - physiology ; Endothelial cells ; Endothelium ; Endothelium, Vascular - cytology ; Endothelium, Vascular - physiology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; HLA-DR Antigens - analysis ; Humans ; Immune system ; Immunobiology ; Immunology ; Individualized Instruction ; Lymph ; Lymphocyte Activation ; Lymphocyte Culture Test, Mixed ; Lymphocytes ; Macrophages ; Macrophages - cytology ; Macrophages - immunology ; Macrophages - physiology ; Microfilament Proteins - analysis ; Migration Patterns ; Monocytes ; Monocytes - cytology ; Monocytes - immunology ; Monocytes - physiology ; Monocytes, macrophages ; Myeloid cells: ontogeny, maturation, markers, receptors ; Phagocytosis ; Physiological aspects ; Stimuli ; T lymphocytes ; T-Lymphocytes - immunology</subject><ispartof>Science (American Association for the Advancement of Science), 1998-10, Vol.282 (5388), p.480-483</ispartof><rights>Copyright 1998 American Association for the Advancement of Science</rights><rights>1999 INIST-CNRS</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Oct 16, 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-7f6737180fac917408af619579932d40eb72dba960635bcd4171064a793d049e3</citedby><cites>FETCH-LOGICAL-c509t-7f6737180fac917408af619579932d40eb72dba960635bcd4171064a793d049e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2897845$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2897845$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1675429$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9774276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Randolph, Gwendalyn J.</creatorcontrib><creatorcontrib>Beaulieu, Sylvie</creatorcontrib><creatorcontrib>Lebecque, Serge</creatorcontrib><creatorcontrib>Steinman, Ralph M.</creatorcontrib><creatorcontrib>Muller, William A.</creatorcontrib><title>Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen. These nascent dendritic cells migrated across the endothelium in the ablumenal-to-lumenal direction, as would occur during entry into lymphatics. Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration.</description><subject>Antigen presenting cells</subject><subject>Antigens, CD - analysis</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - analysis</subject><subject>Cell Count</subject><subject>Cell Differentiation</subject><subject>Cell Movement</subject><subject>Cells</subject><subject>Cells, Cultured</subject><subject>Cellular biology</subject><subject>Collagen</subject><subject>Collagens</subject><subject>Cultured cells</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - physiology</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Fundamental and applied biological sciences. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1998-10, Vol.282 (5388), p.480-483 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Antigen presenting cells Antigens, CD - analysis Biological and medical sciences Carrier Proteins - analysis Cell Count Cell Differentiation Cell Movement Cells Cells, Cultured Cellular biology Collagen Collagens Cultured cells Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - physiology Endothelial cells Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology HLA-DR Antigens - analysis Humans Immune system Immunobiology Immunology Individualized Instruction Lymph Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocytes Macrophages Macrophages - cytology Macrophages - immunology Macrophages - physiology Microfilament Proteins - analysis Migration Patterns Monocytes Monocytes - cytology Monocytes - immunology Monocytes - physiology Monocytes, macrophages Myeloid cells: ontogeny, maturation, markers, receptors Phagocytosis Physiological aspects Stimuli T lymphocytes T-Lymphocytes - immunology |
| title | Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking |
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