Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand

Natural killer (NK) cell function is regulated by NK receptors that interact with MHC class I (MHC-I) molecules on target cells. The murine NK receptor Ly49A inhibits NK cell activity by interacting with H-2D d through its C-type-lectin-like NK receptor domain. Here we report the crystal structure o...

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Veröffentlicht in:	Nature (London) 1999-12, Vol.402 (6762), p.623-631
Hauptverfasser:	Tormo, José, Natarajan, Kannan, Margulies, David H., Mariuzza, Roy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Ly Biological and medical sciences Brain Cellular biology Crystallography, X-Ray Escherichia coli Fundamental and applied biological sciences. Psychology Fundamental immunology H-2 Antigens - chemistry Histocompatibility Antigen H-2D Humanities and Social Sciences Humans Immune system Immunobiology Killer Cells, Natural - chemistry Lectins, C-Type Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Macromolecular Substances Models, Molecular Molecular Sequence Data Molecules multidisciplinary Neurons Protein Binding Protein Conformation Protein Folding Receptors, Immunologic - chemistry Receptors, NK Cell Lectin-Like Recombinant Proteins - chemistry Science Science (multidisciplinary) Sequence Alignment Signal Transduction
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