Coordinated Polar Localization of Auxin Efflux Carrier PIN1 by GNOM ARF GEF

The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution in Arabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-10, Vol.286 (5438), p.316-318
Hauptverfasser:	Steinmann, Thomas, Geldner, Niko, Grebe, Markus, Mangold, Stefan, Jackson, Catherine L., Paris, Sonia, Gälweiler, Leo, Palme, Klaus, Jürgens, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factors - metabolism Antibodies Arabidopsis Arabidopsis - cytology Arabidopsis - embryology Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins Auxin Auxins Biological and medical sciences Biological Transport Brefeldin A - pharmacology Cell Membrane - metabolism Cell Polarity Classical genetics, quantitative genetics, hybrids Coding Cytosol - metabolism Daughter cells Developmental genetics Developmental Stages Embryogenesis Embryonic stem cells Embryos Epidermal cells Flowers & plants Fractions Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Hormones Indoleacetic Acids - metabolism Membrane Proteins - metabolism Membrane Transport Proteins Membranes Molecular biology Plant hormones Plant Roots - growth & development Plant Roots - metabolism Protein Conformation Pteridophyta, spermatophyta Recombinant Proteins - metabolism Seedlings Seeds - cytology Seeds - metabolism Solubility Space life sciences Stem cells Subcellular Fractions - metabolism Suspension Vegetals Yeasts
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Beschreibung
Zusammenfassung:	The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution in Arabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos. GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.286.5438.316