Conserved Structures of Mediator and RNA Polymerase II Holoenzyme

Single particles of the mediator of transcriptional regulation (Mediator) and of RNA polymerase II holoenzyme were revealed by electron microscopy and image processing. Mediator alone appeared compact, but at high pH or in the presence of RNA polymerase II it displayed an extended conformation. Holo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-02, Vol.283 (5404), p.985-987
Hauptverfasser:	Asturias, Francisco J., Jiang, Yi Wei, Myers, Lawrence C., Gustafsson, Claes M., Kornberg, Roger D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - metabolism Enzymes Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Fungal Proteins - chemistry Fungal Proteins - metabolism Genetics Holoenzymes - chemistry Holoenzymes - metabolism Hydrogen-Ion Concentration Laboratory Equipment Mice Microbiology Microscopy, Electron Protein Conformation Protein Folding Ribonucleic acid RNA RNA polymerases Temperature Trans-Activators - chemistry Trans-Activators - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Transferases Yeasts
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