Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-Like Receptor-2
Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1999-07, Vol.285 (5428), p.736-739 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Aliprantis, Antonios O. Yang, Ruey-Bing Mark, Melanie R. Suggett, Shelly Devaux, Brigitte Radolf, Justin D. Klimpel, Gary R. Godowski, Paul Zychlinsky, Arturo |
| description | Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-κB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms. |
| doi_str_mv | 10.1126/science.285.5428.736 |
| format | Article |
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All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-κB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.285.5428.736</identifier><identifier>PMID: 10426996</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Antibodies, Monoclonal ; Apoptosis ; B lymphocytes ; Bacteria ; Bacterial Proteins - metabolism ; Bacterial Proteins - pharmacology ; Bacteriology ; Biological and medical sciences ; Cell death ; Cell Line - metabolism ; Cell lines ; Cellular biology ; Cycloheximide - pharmacology ; Cytometry ; Cytotoxicity, Immunologic ; Drosophila Proteins ; Epithelial cells ; Feedback (Response) ; Fundamental and applied biological sciences. Psychology ; Genes, Reporter ; Humans ; Immune system ; Lipopolysaccharide Receptors - analysis ; Lipopolysaccharides - immunology ; Lipoproteins ; Lipoproteins - metabolism ; Lipoproteins - pharmacology ; Logical Thinking ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - metabolism ; Microbiology ; Molecules ; Monocytes - cytology ; Monocytes - immunology ; Monocytes - metabolism ; NF-kappa B - metabolism ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Protein Synthesis Inhibitors - pharmacology ; Proteins ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Receptors ; Receptors, Cell Surface - immunology ; Receptors, Cell Surface - metabolism ; Reporter genes ; Signal Transduction ; Tetradecanoylphorbol Acetate - pharmacology ; Toll-Like Receptor 2 ; Toll-Like Receptors ; Transfection ; Tumor Cells, Cultured</subject><ispartof>Science (American Association for the Advancement of Science), 1999-07, Vol.285 (5428), p.736-739</ispartof><rights>Copyright 1999 American Association for the Advancement of Science</rights><rights>2000 INIST-CNRS</rights><rights>Copyright American Association for the Advancement of Science Jul 30, 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-44c25362b1058a989f52304a2342c8ca69550e250a748ae9cc4cbd0e581214c93</citedby><cites>FETCH-LOGICAL-c539t-44c25362b1058a989f52304a2342c8ca69550e250a748ae9cc4cbd0e581214c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2898490$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2898490$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1219564$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10426996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aliprantis, Antonios O.</creatorcontrib><creatorcontrib>Yang, Ruey-Bing</creatorcontrib><creatorcontrib>Mark, Melanie R.</creatorcontrib><creatorcontrib>Suggett, Shelly</creatorcontrib><creatorcontrib>Devaux, Brigitte</creatorcontrib><creatorcontrib>Radolf, Justin D.</creatorcontrib><creatorcontrib>Klimpel, Gary R.</creatorcontrib><creatorcontrib>Godowski, Paul</creatorcontrib><creatorcontrib>Zychlinsky, Arturo</creatorcontrib><title>Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-Like Receptor-2</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Apoptosis is implicated in the generation and resolution of inflammation in response to bacterial pathogens. All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-κB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.</description><subject>Antibodies, Monoclonal</subject><subject>Apoptosis</subject><subject>B lymphocytes</subject><subject>Bacteria</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacterial Proteins - pharmacology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cell death</subject><subject>Cell Line - metabolism</subject><subject>Cell lines</subject><subject>Cellular biology</subject><subject>Cycloheximide - pharmacology</subject><subject>Cytometry</subject><subject>Cytotoxicity, Immunologic</subject><subject>Drosophila Proteins</subject><subject>Epithelial cells</subject><subject>Feedback (Response)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Reporter</subject><subject>Humans</subject><subject>Immune system</subject><subject>Lipopolysaccharide Receptors - analysis</subject><subject>Lipopolysaccharides - immunology</subject><subject>Lipoproteins</subject><subject>Lipoproteins - metabolism</subject><subject>Lipoproteins - pharmacology</subject><subject>Logical Thinking</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Microbiology</subject><subject>Molecules</subject><subject>Monocytes - cytology</subject><subject>Monocytes - immunology</subject><subject>Monocytes - metabolism</subject><subject>NF-kappa B - metabolism</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Protein Synthesis Inhibitors - pharmacology</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Receptors</subject><subject>Receptors, Cell Surface - immunology</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Reporter genes</subject><subject>Signal Transduction</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Toll-Like Receptor 2</subject><subject>Toll-Like Receptors</subject><subject>Transfection</subject><subject>Tumor Cells, Cultured</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90U1rGzEQBmBRWhon6T8IRZTSnNaVRh8rHR3TJAVDoThnIY_lRO565Uq7gfz7KrVpSg89CaRnhhm9hFxwNuUc9OeCMfQYpmDUVEkw01boV2TCmVWNBSZekwljQjeGteqEnJayZay-WfGWnHAmQVurJ2Q5D11HZzjERz_E1FPfr-lsn_ZDKrHQ1RO98jiEHH1HF7He5zSE2Be6fMhpvH-gy9R1zSL-CPR7wFDLcgPn5M3GdyW8O55n5O76y3J-2yy-3XydzxYNKmGHRkoEJTSsOFPGW2M3CgSTHoQENOi1VYoFUMy30vhgESWu1iwow4FLtOKMXB761ql-jqEMbhcL1oV8H9JYXCuFltoIXeWn_0regtaa8Qo__AO3acx93cIBF8oCV6IieUCYUyk5bNw-x53PT44z9xyOO4bjajjuORzX_h7i_bH3uNqF9V9FhzQq-HgEvqDvNtn3GMuLA26VlpVdHNi21O_-8wzGGmmZ-AXEhKBp</recordid><startdate>19990730</startdate><enddate>19990730</enddate><creator>Aliprantis, Antonios O.</creator><creator>Yang, Ruey-Bing</creator><creator>Mark, Melanie R.</creator><creator>Suggett, Shelly</creator><creator>Devaux, Brigitte</creator><creator>Radolf, Justin D.</creator><creator>Klimpel, Gary R.</creator><creator>Godowski, Paul</creator><creator>Zychlinsky, Arturo</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7T5</scope></search><sort><creationdate>19990730</creationdate><title>Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-Like Receptor-2</title><author>Aliprantis, Antonios O. ; Yang, Ruey-Bing ; Mark, Melanie R. ; Suggett, Shelly ; Devaux, Brigitte ; Radolf, Justin D. ; Klimpel, Gary R. ; Godowski, Paul ; Zychlinsky, Arturo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-44c25362b1058a989f52304a2342c8ca69550e250a748ae9cc4cbd0e581214c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antibodies, Monoclonal</topic><topic>Apoptosis</topic><topic>B lymphocytes</topic><topic>Bacteria</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacterial Proteins - pharmacology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cell death</topic><topic>Cell Line - metabolism</topic><topic>Cell lines</topic><topic>Cellular biology</topic><topic>Cycloheximide - pharmacology</topic><topic>Cytometry</topic><topic>Cytotoxicity, Immunologic</topic><topic>Drosophila Proteins</topic><topic>Epithelial cells</topic><topic>Feedback (Response)</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Reporter</topic><topic>Humans</topic><topic>Immune system</topic><topic>Lipopolysaccharide Receptors - analysis</topic><topic>Lipopolysaccharides - immunology</topic><topic>Lipoproteins</topic><topic>Lipoproteins - metabolism</topic><topic>Lipoproteins - pharmacology</topic><topic>Logical Thinking</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Microbiology</topic><topic>Molecules</topic><topic>Monocytes - cytology</topic><topic>Monocytes - immunology</topic><topic>Monocytes - metabolism</topic><topic>NF-kappa B - metabolism</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Protein Synthesis Inhibitors - pharmacology</topic><topic>Proteins</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Receptors</topic><topic>Receptors, Cell Surface - 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All bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-κB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>10426996</pmid><doi>10.1126/science.285.5428.736</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1999-07, Vol.285 (5428), p.736-739 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743646836 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Antibodies, Monoclonal Apoptosis B lymphocytes Bacteria Bacterial Proteins - metabolism Bacterial Proteins - pharmacology Bacteriology Biological and medical sciences Cell death Cell Line - metabolism Cell lines Cellular biology Cycloheximide - pharmacology Cytometry Cytotoxicity, Immunologic Drosophila Proteins Epithelial cells Feedback (Response) Fundamental and applied biological sciences. Psychology Genes, Reporter Humans Immune system Lipopolysaccharide Receptors - analysis Lipopolysaccharides - immunology Lipoproteins Lipoproteins - metabolism Lipoproteins - pharmacology Logical Thinking Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Microbiology Molecules Monocytes - cytology Monocytes - immunology Monocytes - metabolism NF-kappa B - metabolism Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Protein Synthesis Inhibitors - pharmacology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Receptors Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Reporter genes Signal Transduction Tetradecanoylphorbol Acetate - pharmacology Toll-Like Receptor 2 Toll-Like Receptors Transfection Tumor Cells, Cultured |
| title | Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-Like Receptor-2 |
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