β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene occur in most human colon cancers. Loss of functional APC protein results in the accumulation of β-catenin. Mutant forms of β-catenin have been discovered in colon cancersthat retain wild-type APC genes,, and also in melanomas,...

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Veröffentlicht in:	Nature (London) 1999-04, Vol.398 (6726), p.422-426
Hauptverfasser:	McCormick, Frank, Tetsu, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation beta Catenin Binding Sites Biological and medical sciences Blotting, Western Cell Division - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Colonic Neoplasms - genetics Colorectal cancer Consensus Sequence Cyclin D1 - genetics Cytoskeletal Proteins - genetics Cytoskeletal Proteins - physiology Fundamental and applied biological sciences. Psychology G1 Phase Gene Expression Regulation, Neoplastic Genes HeLa Cells Humanities and Social Sciences Humans letter Luciferases - genetics Molecular and cellular biology multidisciplinary Mutagenesis, Site-Directed Mutation Promoter Regions, Genetic Prostate cancer Proteins ras Proteins - physiology Recombinant Fusion Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Science Science (multidisciplinary) TCF Transcription Factors Trans-Activators Transcription Factor 7-Like 2 Protein Transcription Factors - metabolism Transcription, Genetic Tumor Cells, Cultured
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