Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

Environmental stimuli that are reliably associated with the effects of many abused drugs, especially stimulants such as cocaine, can produce craving and relapse in abstinent human substance abusers 1 , 2 , 3 , 4 . In animals, such cues can induce and maintain drug-seeking behaviour and also reinstat...

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Veröffentlicht in:	Nature (London) 1999-07, Vol.400 (6742), p.371-375
Hauptverfasser:	Pilla, Maria, Perachon, Sylvie, Sautel, FranÇois, Garrido, Fabrice, Mann, André, Wermuth, Camille G., Schwartz, Jean-Charles, Everitt, Barry J., Sokoloff, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Addictive Behavioral psychophysiology Biological and medical sciences Cell Line CHO Cells Cocaine Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - metabolism Cocaine-Related Disorders - psychology Corpus Striatum - drug effects Corpus Striatum - metabolism Cricetinae Dopamine Agonists - pharmacology Drug abuse Drug addiction Drug therapy Fundamental and applied biological sciences. Psychology Genes, fos Humanities and Social Sciences Humans letter Male Mice multidisciplinary Neurotransmission and behavior Piperazines - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 Recombinant Proteins - metabolism Reinforcement, Psychology Science Science (multidisciplinary) Self Administration Species extinction Substance abuse treatment
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