Pyrimidines as cofactors for phenylalanine hydroxylase

It has been generally assumed that a tetrahydropterin (2-amino-5,6,7,8-tetrahydro-4-pteridinone) is essential for activity of the three aromatic amino acid hydroxylases. In this report it is shown that appropriately substituted pyrimidines can assume the role of cofactor for phenylalanine hydroxylas...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-12, Vol.85 (4), p.1614-1621
Hauptverfasser:	Bailey, S.W., Ayling, J.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopterins - pharmacology Chemical Phenomena Chemistry Kinetics Phenylalanine Hydroxylase - metabolism Pteridines - pharmacology Pyrimidinones - pharmacology Structure-Activity Relationship
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