Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor
A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant K$_d$ ≈ 6 nM) and is functionally coupled to increases in intr...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1991-11, Vol.254 (5034), p.1022-1024 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1024 |
|---|---|
| container_issue | 5034 |
| container_start_page | 1022 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 254 |
| creator | Lin, Herbert Y. Harris, Tonja L. Flannery, Merilee S. Aruffo, Alejandro Kaji, Eugene H. Gorn, Alan Kolakowski, Lee F. Lodish, Harvey F. Goldring, Steven R. |
| description | A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant K$_d$ ≈ 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors. |
| doi_str_mv | 10.1126/science.1658940 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_743581293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A11600040</galeid><jstor_id>2879718</jstor_id><sourcerecordid>A11600040</sourcerecordid><originalsourceid>FETCH-LOGICAL-c744t-3cf367b8f23769f6e18aa90ec3dec70e25d021fcb0bd67396c9fceb7682eb69e3</originalsourceid><addsrcrecordid>eNqN0s1r2zAYB2AxNrqs23mXDcwO2w51K1m2ZB0z02aFsMC-rkKWXwUHxfIkG5r_fgoxHRlhCzoI9D76_iH0muBrQjJ2E3QLnYZrwopS5PgJmhEsilRkmD5FM4wpS0vMi-foRQgbjGNN0At0MfEZurt96D2E0Louqazr2m6dOJOoLpk30O2sGiCpdtqqAGnlxt5Ck1TK6nbY2-QraOgH51-iZ0bZAK-m_hL9uLv9Xn1Ol6vFfTVfpprn-ZBSbSjjdWkyypkwDEiplMCgaQOaY8iKBmfE6BrXDeNUMC2MhpqzMoOaCaCX6MNh3d67XyOEQW7boMFa1YEbg-Q5LUqSCRrl-3_LLOdFPMx_IWGYEVHs4bu_4MaNvovXlRmhRdwXlxFdHdBaWZBtZ9zglV5DB17F5wXTxuE5iYtinOPI0xM8tga2rT7lPx75SAZ4GNZqDEHef_tyNl39PJt-WpxLy8XyiF6dotpZC2uQMRfV6ojfHLj2LgQPRva-3Sq_kwTLfdbllHU5hTfOeDt9yFhvofnjH-tvDvVNiBF9LGclF5yU9DcGuP5C</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213558108</pqid></control><display><type>article</type><title>Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Lin, Herbert Y. ; Harris, Tonja L. ; Flannery, Merilee S. ; Aruffo, Alejandro ; Kaji, Eugene H. ; Gorn, Alan ; Kolakowski, Lee F. ; Lodish, Harvey F. ; Goldring, Steven R.</creator><creatorcontrib>Lin, Herbert Y. ; Harris, Tonja L. ; Flannery, Merilee S. ; Aruffo, Alejandro ; Kaji, Eugene H. ; Gorn, Alan ; Kolakowski, Lee F. ; Lodish, Harvey F. ; Goldring, Steven R.</creatorcontrib><description>A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant K$_d$ ≈ 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1658940</identifier><identifier>PMID: 1658940</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Adenylyl Cyclases - physiology ; Amino Acid Sequence ; Animals ; Blotting, Northern ; Calcitonin ; Calcitonin - metabolism ; Cellular biology ; Cloning ; Cloning, Molecular ; Cyclic AMP - physiology ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Gene Expression ; genes ; Genetics ; Hormone receptors ; Hormones ; Kidney - physiology ; Molecular Sequence Data ; Proteins ; Receptors, Calcitonin ; Receptors, Cell Surface - genetics ; RNA, Messenger - genetics ; Swine</subject><ispartof>Science (American Association for the Advancement of Science), 1991-11, Vol.254 (5034), p.1022-1024</ispartof><rights>Copyright 1991 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 15, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c744t-3cf367b8f23769f6e18aa90ec3dec70e25d021fcb0bd67396c9fceb7682eb69e3</citedby><cites>FETCH-LOGICAL-c744t-3cf367b8f23769f6e18aa90ec3dec70e25d021fcb0bd67396c9fceb7682eb69e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2879718$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2879718$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1658940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Herbert Y.</creatorcontrib><creatorcontrib>Harris, Tonja L.</creatorcontrib><creatorcontrib>Flannery, Merilee S.</creatorcontrib><creatorcontrib>Aruffo, Alejandro</creatorcontrib><creatorcontrib>Kaji, Eugene H.</creatorcontrib><creatorcontrib>Gorn, Alan</creatorcontrib><creatorcontrib>Kolakowski, Lee F.</creatorcontrib><creatorcontrib>Lodish, Harvey F.</creatorcontrib><creatorcontrib>Goldring, Steven R.</creatorcontrib><title>Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant K$_d$ ≈ 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors.</description><subject>Adenylyl Cyclases - physiology</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Blotting, Northern</subject><subject>Calcitonin</subject><subject>Calcitonin - metabolism</subject><subject>Cellular biology</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Cyclic AMP - physiology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Gene Expression</subject><subject>genes</subject><subject>Genetics</subject><subject>Hormone receptors</subject><subject>Hormones</subject><subject>Kidney - physiology</subject><subject>Molecular Sequence Data</subject><subject>Proteins</subject><subject>Receptors, Calcitonin</subject><subject>Receptors, Cell Surface - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>Swine</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0s1r2zAYB2AxNrqs23mXDcwO2w51K1m2ZB0z02aFsMC-rkKWXwUHxfIkG5r_fgoxHRlhCzoI9D76_iH0muBrQjJ2E3QLnYZrwopS5PgJmhEsilRkmD5FM4wpS0vMi-foRQgbjGNN0At0MfEZurt96D2E0Louqazr2m6dOJOoLpk30O2sGiCpdtqqAGnlxt5Ck1TK6nbY2-QraOgH51-iZ0bZAK-m_hL9uLv9Xn1Ol6vFfTVfpprn-ZBSbSjjdWkyypkwDEiplMCgaQOaY8iKBmfE6BrXDeNUMC2MhpqzMoOaCaCX6MNh3d67XyOEQW7boMFa1YEbg-Q5LUqSCRrl-3_LLOdFPMx_IWGYEVHs4bu_4MaNvovXlRmhRdwXlxFdHdBaWZBtZ9zglV5DB17F5wXTxuE5iYtinOPI0xM8tga2rT7lPx75SAZ4GNZqDEHef_tyNl39PJt-WpxLy8XyiF6dotpZC2uQMRfV6ojfHLj2LgQPRva-3Sq_kwTLfdbllHU5hTfOeDt9yFhvofnjH-tvDvVNiBF9LGclF5yU9DcGuP5C</recordid><startdate>19911115</startdate><enddate>19911115</enddate><creator>Lin, Herbert Y.</creator><creator>Harris, Tonja L.</creator><creator>Flannery, Merilee S.</creator><creator>Aruffo, Alejandro</creator><creator>Kaji, Eugene H.</creator><creator>Gorn, Alan</creator><creator>Kolakowski, Lee F.</creator><creator>Lodish, Harvey F.</creator><creator>Goldring, Steven R.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>M81</scope><scope>7X8</scope></search><sort><creationdate>19911115</creationdate><title>Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor</title><author>Lin, Herbert Y. ; Harris, Tonja L. ; Flannery, Merilee S. ; Aruffo, Alejandro ; Kaji, Eugene H. ; Gorn, Alan ; Kolakowski, Lee F. ; Lodish, Harvey F. ; Goldring, Steven R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c744t-3cf367b8f23769f6e18aa90ec3dec70e25d021fcb0bd67396c9fceb7682eb69e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adenylyl Cyclases - physiology</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Blotting, Northern</topic><topic>Calcitonin</topic><topic>Calcitonin - metabolism</topic><topic>Cellular biology</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Cyclic AMP - physiology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>Gene Expression</topic><topic>genes</topic><topic>Genetics</topic><topic>Hormone receptors</topic><topic>Hormones</topic><topic>Kidney - physiology</topic><topic>Molecular Sequence Data</topic><topic>Proteins</topic><topic>Receptors, Calcitonin</topic><topic>Receptors, Cell Surface - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Herbert Y.</creatorcontrib><creatorcontrib>Harris, Tonja L.</creatorcontrib><creatorcontrib>Flannery, Merilee S.</creatorcontrib><creatorcontrib>Aruffo, Alejandro</creatorcontrib><creatorcontrib>Kaji, Eugene H.</creatorcontrib><creatorcontrib>Gorn, Alan</creatorcontrib><creatorcontrib>Kolakowski, Lee F.</creatorcontrib><creatorcontrib>Lodish, Harvey F.</creatorcontrib><creatorcontrib>Goldring, Steven R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>Biochemistry Abstracts 3</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Herbert Y.</au><au>Harris, Tonja L.</au><au>Flannery, Merilee S.</au><au>Aruffo, Alejandro</au><au>Kaji, Eugene H.</au><au>Gorn, Alan</au><au>Kolakowski, Lee F.</au><au>Lodish, Harvey F.</au><au>Goldring, Steven R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1991-11-15</date><risdate>1991</risdate><volume>254</volume><issue>5034</issue><spage>1022</spage><epage>1024</epage><pages>1022-1024</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant K$_d$ ≈ 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>1658940</pmid><doi>10.1126/science.1658940</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1991-11, Vol.254 (5034), p.1022-1024 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743581293 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adenylyl Cyclases - physiology Amino Acid Sequence Animals Blotting, Northern Calcitonin Calcitonin - metabolism Cellular biology Cloning Cloning, Molecular Cyclic AMP - physiology Deoxyribonucleic acid DNA DNA - genetics Gene Expression genes Genetics Hormone receptors Hormones Kidney - physiology Molecular Sequence Data Proteins Receptors, Calcitonin Receptors, Cell Surface - genetics RNA, Messenger - genetics Swine |
| title | Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T00%3A58%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20Cloning%20of%20an%20Adenylate%20Cyclase-Coupled%20Calcitonin%20Receptor&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Lin,%20Herbert%20Y.&rft.date=1991-11-15&rft.volume=254&rft.issue=5034&rft.spage=1022&rft.epage=1024&rft.pages=1022-1024&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1658940&rft_dat=%3Cgale_proqu%3EA11600040%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213558108&rft_id=info:pmid/1658940&rft_galeid=A11600040&rft_jstor_id=2879718&rfr_iscdi=true |