Yeast Hybrid Provides Insight into the Evolution of Gene Expression Regulation

During evolution, novel phenotypes emerge through changes in gene expression, but the genetic basis is poorly understood. We compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from ch...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2009-05, Vol.324 (5927), p.659-662
Hauptverfasser:	Tirosh, Itay, Reikhav, Sharon, Levy, Avraham A, Barkai, Naama
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biodiversity Biological and medical sciences Biological evolution Chromatin Correlations Culture Media Evolution & development Evolution, Molecular Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Fungal Genes Genes, Fungal Genetic mutation Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genome, Fungal Genomes Genotype & phenotype Glycerol - metabolism Hot Temperature Hybridity Hybridization Hybridization, Genetic Molecular and cellular biology Molecular genetics Mutation Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Saccharomyces - genetics Saccharomyces - growth & development Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Shock heating Species Specificity TATA Box Transcription. Transcription factor. Splicing. Rna processing Yeast Yeasts
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