Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease
The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [11C]raclopride binding as measured by...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2001-08, Vol.293 (5532), p.1164-1166 |
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| creator | de la Fuente-Fernández, Raúl Ruth, Thomas J. Sossi, Vesna Schulzer, Michael Calne, Donald B. Stoessl, A. Jon |
| description | The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [11C]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PD patients in response to placebo. Our findings indicate that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system. |
| doi_str_mv | 10.1126/science.1060937 |
| format | Article |
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Our findings indicate that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1060937</identifier><identifier>PMID: 11498597</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Aged ; Antiparkinson Agents - administration & dosage ; Antiparkinson Agents - therapeutic use ; Apomorphine - administration & dosage ; Apomorphine - therapeutic use ; Biological and medical sciences ; Brain ; Caudate nucleus ; Clinical trials ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dopamine - metabolism ; Dosage ; Expectation ; Female ; Humans ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Narcotics ; Neurology ; Neurotransmitters ; Parkinson disease ; Parkinson Disease - drug therapy ; Parkinson Disease - metabolism ; Parkinson's disease ; Patients ; PET scanners ; Placebo Effect ; Placebos ; Placebos - administration & dosage ; Positron emission tomography ; Putamen ; Raclopride - metabolism ; Synapses - metabolism ; Tomography, Emission-Computed</subject><ispartof>Science (American Association for the Advancement of Science), 2001-08, Vol.293 (5532), p.1164-1166</ispartof><rights>Copyright 2001 American Association for the Advancement of Science</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Aug 10, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c743t-2399fcc7e81fa0c17da6d0a1cba128e5984e43200592056fd2384ff8909796813</citedby><cites>FETCH-LOGICAL-c743t-2399fcc7e81fa0c17da6d0a1cba128e5984e43200592056fd2384ff8909796813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3084390$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3084390$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1120266$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11498597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de la Fuente-Fernández, Raúl</creatorcontrib><creatorcontrib>Ruth, Thomas J.</creatorcontrib><creatorcontrib>Sossi, Vesna</creatorcontrib><creatorcontrib>Schulzer, Michael</creatorcontrib><creatorcontrib>Calne, Donald B.</creatorcontrib><creatorcontrib>Stoessl, A. Jon</creatorcontrib><title>Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [11C]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PD patients in response to placebo. Our findings indicate that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.</description><subject>Aged</subject><subject>Antiparkinson Agents - administration & dosage</subject><subject>Antiparkinson Agents - therapeutic use</subject><subject>Apomorphine - administration & dosage</subject><subject>Apomorphine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Caudate nucleus</subject><subject>Clinical trials</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - metabolism</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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| ispartof | Science (American Association for the Advancement of Science), 2001-08, Vol.293 (5532), p.1164-1166 |
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| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Aged Antiparkinson Agents - administration & dosage Antiparkinson Agents - therapeutic use Apomorphine - administration & dosage Apomorphine - therapeutic use Biological and medical sciences Brain Caudate nucleus Clinical trials Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - metabolism Dosage Expectation Female Humans Male Medical sciences Medical treatment Middle Aged Narcotics Neurology Neurotransmitters Parkinson disease Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Patients PET scanners Placebo Effect Placebos Placebos - administration & dosage Positron emission tomography Putamen Raclopride - metabolism Synapses - metabolism Tomography, Emission-Computed |
| title | Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease |
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