VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

The multidomain proapoptotic molecules BAK or BAX are required to initiate the mitochondrial pathway of apoptosis. How cells maintain the potentially lethal proapoptotic effector BAK in a monomeric inactive conformation at mitochondria is unknown. In viable cells, we found BAK complexed with mitocho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-07, Vol.301 (5632), p.513-517
Hauptverfasser:	Emily H. -Y. Cheng, Sheiko, Tatiana V., Fisher, Jill K., Craigen, William J., Korsmeyer, Stanley J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis bcl-2 Homologous Antagonist-Killer Protein bcl-2-Associated X Protein BH3 Interacting Domain Death Agonist Protein Biological and medical sciences Biopolymers Carrier Proteins - metabolism Carrier Proteins - pharmacology Cell death Cell Line Cell lines Cell physiology Cells Cells, Cultured Cellular biology Cytochromes Etoposide - pharmacology Fundamental and applied biological sciences. Psychology Genetics Humans Intracellular Membranes - metabolism Jurkat Cells Liver cells Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Mitochondria, Liver - metabolism Molecular and cellular biology Molecules Porins - genetics Porins - isolation & purification Porins - metabolism Protein Binding Protein Conformation Protein isoforms Protein Structure, Tertiary Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Recombinant Proteins - pharmacology Staurosporine - pharmacology Stimuli Voltage-Dependent Anion Channel 1 Voltage-Dependent Anion Channel 2 Voltage-Dependent Anion Channels
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!