Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements

Pit-1, a tissue-specific POU domain transcription factor, is required for the activation of the prolactin, growth hormone, and Pit-1 promoters that confer regulation by epidermal growth factor, adenosine 3′,5′-monophosphate (cAMP), and phorbol esters. Pit-1 is phosphorylated in pituitary cells at tw...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1991-08, Vol.253 (5021), p.786-789
Hauptverfasser:	Kapiloff, Michael S., Farkash, Yigal, Wegner, Michael, Rosenfeld, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Binding Sites Biological and medical sciences Cell Line Cell lines Cellular biology Cyclic AMP - pharmacology Deoxyribonucleic acid DNA DNA - metabolism DNA binding proteins DNA-Binding Proteins - chemistry DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Gels Genes Genetic transcription Growth hormones Hormones In Vitro Techniques Molecular and cellular biology Molecular genetics Molecular Sequence Data Peptide Mapping Phorbol esters Phosphorylation Phosphothreonine - metabolism Pituitary Gland - physiology Protein Kinases - metabolism Radioactive decay Regulatory Sequences, Nucleic Acid Sequencing Structure-Activity Relationship Tetradecanoylphorbol Acetate - pharmacology Transcription (Genetics) Transcription Factor Pit-1 Transcription Factors - chemistry Transcription Factors - physiology Transcription. Transcription factor. Splicing. Rna processing Transcriptional regulatory elements Trypsin
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