Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

γ-Aminobutyric acid (GABA) B receptors couple to G o to inhibit N-type calcium channels in embryonic chick dorsal root ganglion neurons 1 . The voltage-independent inhibition, mediated by means of a tyrosine-kinase pathway 2 , is transient and lasts up to 100 seconds. Inhibition of endogenous RGS12,...

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Veröffentlicht in:	Nature (London) 2000-12, Vol.408 (6813), p.723-727
Hauptverfasser:	Schiff, Max L., Siderovski, David P., Jordan, J. Dedrick, Brothers, Greg, Snow, Bryan, De Vries, Luc, Ortiz, Daniel F., Diversé-Pierluissi, María
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biology Calcium Calcium - metabolism Calcium channels Calcium Channels, N-Type - metabolism Cell physiology Cells, Cultured Chick Embryo Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Humanities and Social Sciences Humans letter Molecular and cellular biology Molecular Sequence Data multidisciplinary Neurons Neurons - metabolism Phosphorylation Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Proteins Rats Receptors, GABA-B - metabolism Recombinant Fusion Proteins RGS protein RGS Proteins - genetics RGS Proteins - metabolism Science Signal Transduction
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