Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi

Transposable elements are stretches of DNA that can move and multiply within the genome of an organism. The Caenorhabditis elegans genome contains multiple Tc 1 transposons that jump in somatic cells, but are silenced in the germ line 1 , 2 , 3 . Many mutants that have lost this silencing have also...

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Veröffentlicht in:	Nature (London) 2003-11, Vol.426 (6964), p.310-314
Hauptverfasser:	Sijen, Titia, Plasterk, Ronald H. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Animals, Genetically Modified Bacteria Biological and medical sciences Caenorhabditis elegans - genetics DNA Transposable Elements - genetics Fundamental and applied biological sciences. Psychology Gene expression Genes, Helminth - genetics Germ Cells - metabolism Humanities and Social Sciences letter Molecular and cellular biology Molecular genetics multidisciplinary Nuclease Protection Assays Promoter Regions, Genetic - genetics Ribonucleic acid RNA RNA Editing RNA Interference RNA Splicing RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA, Helminth - genetics RNA, Helminth - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Science Science (multidisciplinary) Terminal Repeat Sequences - genetics Transcription, Genetic - genetics Transgenes - genetics
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