Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH). Here, we report that neural projection pathways from the ARH are permanently disrupted in leptin-deficient ($Lep^{ob}...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-04, Vol.304 (5667), p.108-110
Hauptverfasser:	Bouret, Sebastien G., Draper, Shin J., Simerly, Richard B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Agouti-Related Protein alpha-MSH - analysis Animals Animals, Newborn Arcuate Nucleus of Hypothalamus - cytology Arcuate Nucleus of Hypothalamus - growth & development Arcuate Nucleus of Hypothalamus - physiology Axons - physiology Biological and medical sciences Brain Carbocyanines Chemical properties Critical periods Culture Techniques Dorsomedial Hypothalamic Nucleus - cytology Dorsomedial Hypothalamic Nucleus - growth & development Dorsomedial Hypothalamic Nucleus - physiology Eating Eating (Physiology) Feeding Behavior Feeding. Feeding behavior Food intake Fundamental and applied biological sciences. Psychology Hormones Hypothalamic Area, Lateral - cytology Hypothalamic Area, Lateral - growth & development Hypothalamic Area, Lateral - physiology Hypothalamus Hypothalamus - cytology Hypothalamus - growth & development Hypothalamus - physiology Innervation Intercellular Signaling Peptides and Proteins Leptin Leptin - deficiency Leptin - genetics Leptin - pharmacology Leptin - physiology Mice Mice, Inbred C57BL Mice, Obese Neonates Nerve Fibers - physiology Neurites Neurites - physiology Neurology Neurons Neurons - physiology Neuroscience Nutrition Obesity Paraventricular Hypothalamic Nucleus - cytology Paraventricular Hypothalamic Nucleus - growth & development Paraventricular Hypothalamic Nucleus - physiology Physiological aspects Proteins - analysis Recombinant Proteins - pharmacology Rodents Signal Transduction Vertebrates: anatomy and physiology, studies on body, several organs or systems
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