Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos

Asymmetric divisions are crucial for generating cell diversity; they rely on coupling between polarity cues and spindle positioning, but how this coupling is achieved is poorly understood. In one-cell stage Caenorhabditis elegans embryos, polarity cues set by the PAR proteins mediate asymmetric spin...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-06, Vol.300 (5627), p.1957-1961
Hauptverfasser:	Colombo, Kelly, Grill, Stephan W., Kimple, Randall J., Willard, Francis S., Siderovski, David P., Gönczy, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Animals Animals, Genetically Modified Biological and medical sciences Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell cycle Cell Division Cell Polarity Cellular biology Cues Early stages. Segmentation. Gastrulation. Neurulation Embryogenesis Embryology: invertebrates and vertebrates. Teratology Embryos Epidemics Fundamental and applied biological sciences. Psychology Grade Point Average GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Literary Devices Long term potentiation Muscle spindles Neurons Neuroscience Phenotype Phenotypes Protein Subunits - genetics Protein Subunits - metabolism Recombinant Fusion Proteins - metabolism RNA Interference Signal Transduction Spindle Apparatus - physiology Spindle Apparatus - ultrastructure Two-Hybrid System Techniques
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