A NEW CEPHALOSPORIN. SCE-963: 7-[2-(2-AMINOTHIAZOL-4-YL)- ACETAMIDO]-3-[[[1-(2-DIMETHYLAMINOETHYL)-1H-TETRAZOL-5-YL]- THIO]METHYL]CEPH-3-EM-4-CARBOXYLIC ACID: CHEMISTRY AND STRUCTURE-ACTIVITY RELATIONSHIPS

The synthesis and the in vitro and in vivo antimicrobial activities of a series of 7-[2-(2-aminothiazol-4-yl)acetamido]cephalosporins (1) having varied 3-substituents, such as methyl, hydroxymethyl, acetoxymethyl, pyridiniomethyl and heterocyclicthiomethyls, are described. The derivatives having fiv...

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Veröffentlicht in:	Journal of antibiotics 1978, Vol.31(12), pp.1262-1271
Hauptverfasser:	NUMATA, MITSUO, MINAMIDA, ISAO, YAMAOKA, MASAYOSHI, SHIRAISHI, MITSURU, MIYAWAKI, TOSHIO, AKIMOTO, HIROSHI, NAITO, KENZO, KIDA, MAKOTO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria - drug effects Cephalosporins - chemical synthesis Cephalosporins - pharmacology Cephalosporins - therapeutic use Escherichia coli Infections - drug therapy Male Mice Mice, Inbred ICR Microbial Sensitivity Tests Structure-Activity Relationship
Online-Zugang:	Volltext
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