Maternal-Zygotic Transition: Death and Birth of RNAs
Maternal gene products drive early development when the newly formed embryo is transcriptionally inactive. During the maternal-zygotic transition, embryonic transcription is initiated and many maternal RNAs are degraded. Multiple mechanisms regulate the birth of zygotic RNAs and the death of materna...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2007-04, Vol.316 (5823), p.406-407 |
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| creator | Schier, Alexander F |
| description | Maternal gene products drive early development when the newly formed embryo is transcriptionally inactive. During the maternal-zygotic transition, embryonic transcription is initiated and many maternal RNAs are degraded. Multiple mechanisms regulate the birth of zygotic RNAs and the death of maternal RNAs. Genome activation appears to rely in part on the sequestration of transcriptional repressors by the exponentially increasing amount of DNA during cleavage divisions. Maternal RNA degradation is induced by the binding of proteins and microRNAs to the 3' untranslated region of target RNAs. |
| doi_str_mv | 10.1126/science.1140693 |
| format | Article |
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During the maternal-zygotic transition, embryonic transcription is initiated and many maternal RNAs are degraded. Multiple mechanisms regulate the birth of zygotic RNAs and the death of maternal RNAs. Genome activation appears to rely in part on the sequestration of transcriptional repressors by the exponentially increasing amount of DNA during cleavage divisions. 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| ispartof | Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5823), p.406-407 |
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| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | 3' Untranslated Regions Animals Binding sites Cell Cycle Cells Cellular biology DNA Embryology Embryonic Development Embryos Female Gene Expression Regulation, Developmental Gene Silencing Genes Genomes Genomics Germ cells Messenger RNA MicroRNAs Mothers Reviews Ribonucleic acid RNA RNA Stability RNA, Messenger - metabolism RNA, Messenger, Stored - metabolism RNA-Binding Proteins - metabolism Stem cells Transcription, Genetic Zygote - cytology Zygote - metabolism |
| title | Maternal-Zygotic Transition: Death and Birth of RNAs |
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