Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility

Segmental duplications in the human genome are selectively enriched for genes involved in immunity, although the phenotypic consequences for host defense are unknown. We show that there are significant interindividual and interpopulation differences in the copy number of a segmental duplication enco...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2005-03, Vol.307 (5714), p.1434-1440
Hauptverfasser:	Gonzalez, Enrique, Kulkarni, Hemant, Bolivar, Hector, Mangano, Andrea, Sanchez, Racquel, Catano, Gabriel, Nibbs, Robert J, Freedman, Barry I, Quinones, Marlon P, Bamshad, Michael J, Murthy, Krishna K, Rovin, Brad H, Bradley, William, Clark, Robert A, Anderson, Stephanie A, O'Connell, Robert J, Agan, Brian K, Ahuja, Seema S, Bologna, Rosa, Sen, Luisa, Dolan, Matthew J, Ahuja, Sunil K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome (AIDS) Adolescent Adult Adults Aged AIDS Animals Chemokines, CC - genetics Chemokines, CC - metabolism Child Cohort Studies Continental Population Groups - genetics Disease Progression Dosage Ethnic Groups - genetics Female Gene Dosage Gene Duplication Genes Genetic Predisposition to Disease Genetic research Genotype Genotype & phenotype Genotypes HIV HIV antibodies HIV infection HIV infections HIV Infections - epidemiology HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 - metabolism Human genetics Human genome Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunity Immunity (Physiology) Infections Male Medical genetics Middle Aged Numbers Pan troglodytes - genetics Phenotype Public Health Receptors, CCR5 - genetics Receptors, CCR5 - metabolism Selection, Genetic Statistical Analysis Statistical median T lymphocytes
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