The LIM homeobox gene Lhx9 is essential for mouse gonad formation

During mammalian embryonic development, the ovaries and testes develop from somatic cells of the urogenital ridges as indifferent gonads, harbouring primordial germ cells that have migrated there. After sex determination of the gonads, the testes produce testosterone and anti-Mullerian hormone which...

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Veröffentlicht in:	Nature (London) 2000-02, Vol.403 (6772), p.909-913
Hauptverfasser:	Birk, Ohad S., Casiano, Delane E., Wassif, Christopher A., Cogliati, Tiziana, Zhao, Liping, Zhao, Yangu, Grinberg, Alexander, Huang, SingPing, Kreidberg, Jordan A., Parker, Keith L., Porter, Forbes D., Westphal, Heiner
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromosome Mapping Embryonic growth stage Embryos Female Gene Deletion Genes Genes, Homeobox Gonadal Dysgenesis - genetics Gonads Gonads - abnormalities Gonads - embryology Homeodomain Proteins - genetics Humanities and Social Sciences letter Lhx9 gene LIM-Homeodomain Proteins Male Mice Mice, Inbred C57BL multidisciplinary Reproduction Ridges Rodents Science Science (multidisciplinary) Sex Determination Processes Sex Differentiation - genetics Steroidogenic Factor 1 Testis - embryology Transcription Factors - genetics Transcription Factors - physiology
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