The Genome Sequence of Drosophila melanogaster
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2000-03, Vol.287 (5461), p.2185-2195 |
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| creator | Adams, Mark D. Celniker, Susan E. Evans, Cheryl A. Amanatides, Peter G. Scherer, Steven E. Hoskins, Roger A. Galle, Richard F. Wortman, Jennifer R. Chen, Lin X. Rogers, Yu-Hui C. Blazej, Robert G. Pfeiffer, Barret D. Wan, Kenneth H. Doyle, Clare Baxter, Evan G. Helt, Gregg Abril, Josep F. An, Hui-Jin Baldwin, Danita Ballew, Richard M. Basu, Anand Bayraktaroglu, Leyla Beasley, Ellen M. Beeson, Karen Y. Bolshakov, Slava Borkova, Dana Bouck, John Brokstein, Peter Burtis, Kenneth C. Butler, Heather Cadieu, Edouard Angela Center Cherry, J. Michael Cawley, Simon Davies, Peter de Pablos, Beatriz Dodson, Kristina Doup, Lisa E. Ferraz, Concepcion Fleischmann, Wolfgang Fosler, Carl Gabrielian, Andrei E. Garg, Neha S. Glodek, Anna Gong, Fangcheng Guan, Ping Harris, Michael Houck, Jarrett Hostin, Damon Houston, Kathryn A. Howland, Timothy J. Jalali, Mena Kalush, Francis Ke, Zhaoxi Ketchum, Karen A. Kimmel, Bruce E. Kodira, Chinnappa D. Kraft, Cheryl Kravitz, Saul Lai, Zhongwu Lei, Yiding Li, Zhenya Liang, Yong Lin, Xiaoying Mattei, Bettina McIntosh, Tina C. McPherson, Duncan Milshina, Natalia V. Moy, Mee Murphy, Lee Muzny, Donna M. Nelson, David L. Nelson, David R. Nelson, Keith A. Nixon, Katherine Pan, Sue Pollard, John Reinert, Knut Skupski, Marian P. Spier, Eugene Stapleton, Mark Sun, Eric Svirskas, Robert Turner, Russell Venter, Eli Wang, Xin Wang, Zhen-Yuan Weissenbach, Jean Yang, Song Yao, Q. Alison Ye, Jane Zhan, Ming Zheng, Liansheng Zhong, Wenyan Zhou, Xiaojun Zhu, Shiaoping Zhu, Xiaohong Smith, Hamilton O. Gibbs, Richard A. Rubin, Gerald M. |
| description | The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ∼13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity. |
| doi_str_mv | 10.1126/science.287.5461.2185 |
| format | Article |
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Michael ; Cawley, Simon ; Davies, Peter ; de Pablos, Beatriz ; Dodson, Kristina ; Doup, Lisa E. ; Ferraz, Concepcion ; Fleischmann, Wolfgang ; Fosler, Carl ; Gabrielian, Andrei E. ; Garg, Neha S. ; Glodek, Anna ; Gong, Fangcheng ; Guan, Ping ; Harris, Michael ; Houck, Jarrett ; Hostin, Damon ; Houston, Kathryn A. ; Howland, Timothy J. ; Jalali, Mena ; Kalush, Francis ; Ke, Zhaoxi ; Ketchum, Karen A. ; Kimmel, Bruce E. ; Kodira, Chinnappa D. ; Kraft, Cheryl ; Kravitz, Saul ; Lai, Zhongwu ; Lei, Yiding ; Li, Zhenya ; Liang, Yong ; Lin, Xiaoying ; Mattei, Bettina ; McIntosh, Tina C. ; McPherson, Duncan ; Milshina, Natalia V. ; Moy, Mee ; Murphy, Lee ; Muzny, Donna M. ; Nelson, David L. ; Nelson, David R. ; Nelson, Keith A. ; Nixon, Katherine ; Pan, Sue ; Pollard, John ; Reinert, Knut ; Skupski, Marian P. ; Spier, Eugene ; Stapleton, Mark ; Sun, Eric ; Svirskas, Robert ; Turner, Russell ; Venter, Eli ; Wang, Xin ; Wang, Zhen-Yuan ; Weissenbach, Jean ; Yang, Song ; Yao, Q. Alison ; Ye, Jane ; Zhan, Ming ; Zheng, Liansheng ; Zhong, Wenyan ; Zhou, Xiaojun ; Zhu, Shiaoping ; Zhu, Xiaohong ; Smith, Hamilton O. ; Gibbs, Richard A. ; Rubin, Gerald M.</creator><creatorcontrib>Adams, Mark D. ; Celniker, Susan E. ; Evans, Cheryl A. ; Amanatides, Peter G. ; Scherer, Steven E. ; Hoskins, Roger A. ; Galle, Richard F. ; Wortman, Jennifer R. ; Chen, Lin X. ; Rogers, Yu-Hui C. ; Blazej, Robert G. ; Pfeiffer, Barret D. ; Wan, Kenneth H. ; Doyle, Clare ; Baxter, Evan G. ; Helt, Gregg ; Abril, Josep F. ; An, Hui-Jin ; Baldwin, Danita ; Ballew, Richard M. ; Basu, Anand ; Bayraktaroglu, Leyla ; Beasley, Ellen M. ; Beeson, Karen Y. ; Bolshakov, Slava ; Borkova, Dana ; Bouck, John ; Brokstein, Peter ; Burtis, Kenneth C. ; Butler, Heather ; Cadieu, Edouard ; Angela Center ; Cherry, J. Michael ; Cawley, Simon ; Davies, Peter ; de Pablos, Beatriz ; Dodson, Kristina ; Doup, Lisa E. ; Ferraz, Concepcion ; Fleischmann, Wolfgang ; Fosler, Carl ; Gabrielian, Andrei E. ; Garg, Neha S. ; Glodek, Anna ; Gong, Fangcheng ; Guan, Ping ; Harris, Michael ; Houck, Jarrett ; Hostin, Damon ; Houston, Kathryn A. ; Howland, Timothy J. ; Jalali, Mena ; Kalush, Francis ; Ke, Zhaoxi ; Ketchum, Karen A. ; Kimmel, Bruce E. ; Kodira, Chinnappa D. ; Kraft, Cheryl ; Kravitz, Saul ; Lai, Zhongwu ; Lei, Yiding ; Li, Zhenya ; Liang, Yong ; Lin, Xiaoying ; Mattei, Bettina ; McIntosh, Tina C. ; McPherson, Duncan ; Milshina, Natalia V. ; Moy, Mee ; Murphy, Lee ; Muzny, Donna M. ; Nelson, David L. ; Nelson, David R. ; Nelson, Keith A. ; Nixon, Katherine ; Pan, Sue ; Pollard, John ; Reinert, Knut ; Skupski, Marian P. ; Spier, Eugene ; Stapleton, Mark ; Sun, Eric ; Svirskas, Robert ; Turner, Russell ; Venter, Eli ; Wang, Xin ; Wang, Zhen-Yuan ; Weissenbach, Jean ; Yang, Song ; Yao, Q. Alison ; Ye, Jane ; Zhan, Ming ; Zheng, Liansheng ; Zhong, Wenyan ; Zhou, Xiaojun ; Zhu, Shiaoping ; Zhu, Xiaohong ; Smith, Hamilton O. ; Gibbs, Richard A. ; Rubin, Gerald M.</creatorcontrib><description>The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ∼13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.287.5461.2185</identifier><identifier>PMID: 10731132</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Analysis ; Animals ; Biological Transport - genetics ; Chromatin - genetics ; Chromosome mapping ; Chromosomes ; Cloning, Molecular ; Community Relations ; Computational Biology ; Contig Mapping ; Cytochrome P-450 Enzyme System - genetics ; DNA ; DNA Repair - genetics ; DNA Replication - genetics ; Drosophila ; Drosophila melanogaster - genetics ; Drosophila melanogaster - metabolism ; Euchromatin ; Gene Library ; Genes ; Genes, Insect ; Genome ; Genomes ; Genomics ; Heterochromatin - genetics ; Insect Proteins - chemistry ; Insect Proteins - genetics ; Insect Proteins - physiology ; Insects ; Libraries ; Nuclear Proteins - genetics ; Protein Biosynthesis ; Research Tools ; Reviews ; Scaffolds ; Science and Society ; Sequence Analysis, DNA ; Sequencing ; Transcription, Genetic ; Yeasts</subject><ispartof>Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5461), p.2185-2195</ispartof><rights>Copyright 2000 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2000 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2000 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Mar 24, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c639t-bdae2b7e049292f558bc85f9c53ba8c6c36069c306cb2e5c690c2f894745a62a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3074811$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3074811$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10731132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adams, Mark D.</creatorcontrib><creatorcontrib>Celniker, Susan E.</creatorcontrib><creatorcontrib>Evans, Cheryl A.</creatorcontrib><creatorcontrib>Amanatides, Peter G.</creatorcontrib><creatorcontrib>Scherer, Steven E.</creatorcontrib><creatorcontrib>Hoskins, Roger A.</creatorcontrib><creatorcontrib>Galle, Richard F.</creatorcontrib><creatorcontrib>Wortman, Jennifer R.</creatorcontrib><creatorcontrib>Chen, Lin X.</creatorcontrib><creatorcontrib>Rogers, Yu-Hui C.</creatorcontrib><creatorcontrib>Blazej, Robert G.</creatorcontrib><creatorcontrib>Pfeiffer, Barret D.</creatorcontrib><creatorcontrib>Wan, Kenneth H.</creatorcontrib><creatorcontrib>Doyle, Clare</creatorcontrib><creatorcontrib>Baxter, Evan G.</creatorcontrib><creatorcontrib>Helt, Gregg</creatorcontrib><creatorcontrib>Abril, Josep F.</creatorcontrib><creatorcontrib>An, Hui-Jin</creatorcontrib><creatorcontrib>Baldwin, Danita</creatorcontrib><creatorcontrib>Ballew, Richard M.</creatorcontrib><creatorcontrib>Basu, Anand</creatorcontrib><creatorcontrib>Bayraktaroglu, Leyla</creatorcontrib><creatorcontrib>Beasley, Ellen M.</creatorcontrib><creatorcontrib>Beeson, Karen Y.</creatorcontrib><creatorcontrib>Bolshakov, Slava</creatorcontrib><creatorcontrib>Borkova, Dana</creatorcontrib><creatorcontrib>Bouck, John</creatorcontrib><creatorcontrib>Brokstein, Peter</creatorcontrib><creatorcontrib>Burtis, Kenneth C.</creatorcontrib><creatorcontrib>Butler, Heather</creatorcontrib><creatorcontrib>Cadieu, Edouard</creatorcontrib><creatorcontrib>Angela Center</creatorcontrib><creatorcontrib>Cherry, J. Michael</creatorcontrib><creatorcontrib>Cawley, Simon</creatorcontrib><creatorcontrib>Davies, Peter</creatorcontrib><creatorcontrib>de Pablos, Beatriz</creatorcontrib><creatorcontrib>Dodson, Kristina</creatorcontrib><creatorcontrib>Doup, Lisa E.</creatorcontrib><creatorcontrib>Ferraz, Concepcion</creatorcontrib><creatorcontrib>Fleischmann, Wolfgang</creatorcontrib><creatorcontrib>Fosler, Carl</creatorcontrib><creatorcontrib>Gabrielian, Andrei E.</creatorcontrib><creatorcontrib>Garg, Neha S.</creatorcontrib><creatorcontrib>Glodek, Anna</creatorcontrib><creatorcontrib>Gong, Fangcheng</creatorcontrib><creatorcontrib>Guan, Ping</creatorcontrib><creatorcontrib>Harris, Michael</creatorcontrib><creatorcontrib>Houck, Jarrett</creatorcontrib><creatorcontrib>Hostin, Damon</creatorcontrib><creatorcontrib>Houston, Kathryn A.</creatorcontrib><creatorcontrib>Howland, Timothy J.</creatorcontrib><creatorcontrib>Jalali, Mena</creatorcontrib><creatorcontrib>Kalush, Francis</creatorcontrib><creatorcontrib>Ke, Zhaoxi</creatorcontrib><creatorcontrib>Ketchum, Karen A.</creatorcontrib><creatorcontrib>Kimmel, Bruce E.</creatorcontrib><creatorcontrib>Kodira, Chinnappa D.</creatorcontrib><creatorcontrib>Kraft, Cheryl</creatorcontrib><creatorcontrib>Kravitz, Saul</creatorcontrib><creatorcontrib>Lai, Zhongwu</creatorcontrib><creatorcontrib>Lei, Yiding</creatorcontrib><creatorcontrib>Li, Zhenya</creatorcontrib><creatorcontrib>Liang, Yong</creatorcontrib><creatorcontrib>Lin, Xiaoying</creatorcontrib><creatorcontrib>Mattei, Bettina</creatorcontrib><creatorcontrib>McIntosh, Tina C.</creatorcontrib><creatorcontrib>McPherson, Duncan</creatorcontrib><creatorcontrib>Milshina, Natalia V.</creatorcontrib><creatorcontrib>Moy, Mee</creatorcontrib><creatorcontrib>Murphy, Lee</creatorcontrib><creatorcontrib>Muzny, Donna M.</creatorcontrib><creatorcontrib>Nelson, David L.</creatorcontrib><creatorcontrib>Nelson, David R.</creatorcontrib><creatorcontrib>Nelson, Keith A.</creatorcontrib><creatorcontrib>Nixon, Katherine</creatorcontrib><creatorcontrib>Pan, Sue</creatorcontrib><creatorcontrib>Pollard, John</creatorcontrib><creatorcontrib>Reinert, Knut</creatorcontrib><creatorcontrib>Skupski, Marian P.</creatorcontrib><creatorcontrib>Spier, Eugene</creatorcontrib><creatorcontrib>Stapleton, Mark</creatorcontrib><creatorcontrib>Sun, Eric</creatorcontrib><creatorcontrib>Svirskas, Robert</creatorcontrib><creatorcontrib>Turner, Russell</creatorcontrib><creatorcontrib>Venter, Eli</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Wang, Zhen-Yuan</creatorcontrib><creatorcontrib>Weissenbach, Jean</creatorcontrib><creatorcontrib>Yang, Song</creatorcontrib><creatorcontrib>Yao, Q. Alison</creatorcontrib><creatorcontrib>Ye, Jane</creatorcontrib><creatorcontrib>Zhan, Ming</creatorcontrib><creatorcontrib>Zheng, Liansheng</creatorcontrib><creatorcontrib>Zhong, Wenyan</creatorcontrib><creatorcontrib>Zhou, Xiaojun</creatorcontrib><creatorcontrib>Zhu, Shiaoping</creatorcontrib><creatorcontrib>Zhu, Xiaohong</creatorcontrib><creatorcontrib>Smith, Hamilton O.</creatorcontrib><creatorcontrib>Gibbs, Richard A.</creatorcontrib><creatorcontrib>Rubin, Gerald M.</creatorcontrib><title>The Genome Sequence of Drosophila melanogaster</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ∼13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.</description><subject>Analysis</subject><subject>Animals</subject><subject>Biological Transport - genetics</subject><subject>Chromatin - genetics</subject><subject>Chromosome mapping</subject><subject>Chromosomes</subject><subject>Cloning, Molecular</subject><subject>Community Relations</subject><subject>Computational Biology</subject><subject>Contig Mapping</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>DNA</subject><subject>DNA Repair - genetics</subject><subject>DNA Replication - genetics</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Euchromatin</subject><subject>Gene Library</subject><subject>Genes</subject><subject>Genes, Insect</subject><subject>Genome</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Heterochromatin - genetics</subject><subject>Insect Proteins - chemistry</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - physiology</subject><subject>Insects</subject><subject>Libraries</subject><subject>Nuclear Proteins - genetics</subject><subject>Protein Biosynthesis</subject><subject>Research Tools</subject><subject>Reviews</subject><subject>Scaffolds</subject><subject>Science and Society</subject><subject>Sequence Analysis, DNA</subject><subject>Sequencing</subject><subject>Transcription, Genetic</subject><subject>Yeasts</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0suO0zAUBmALgZhSeANAFQtgMQm-xI69HAqUkSq6mIGt5bgnmVRJ3LETCd4eh1SIogoqLyz5fLaO7R-hFwSnhFDxLtgaOgsplXnKM0FSSiR_gGYEK54oitlDNMOYiUTinF-gJyHsMI41xR6jC4JzRgijM5Te3sFiBZ1rYXED98N45sKViw_eBbe_qxuzaKExnatM6ME_RY9K0wR4dpjn6Ounj7fLz8l6s7peXq0TK5jqk2JrgBY54ExRRUvOZWElL5XlrDDSCssEFsoyLGxBgVuhsKWlVFmecSOoYXP0Zjp3711sKvS6rYOFJnYCbgg6zxjHGc1ElK__LbFSLL7NfyHJOSZK8Qhf_QV3bvBdvK6mhPGcy1_ockKVaUDXXel6b2wFHXjTuA7KOi5fCSIYHz9jjpITPI4ttLU95d8e-Uh6-N5XZghBX998OZtuvp1N36_OpXK1PqKXp6h1TQMV6JiL5eaI84nbGLHgodR7X7fG_9AE6zHa-hBtHaOtx2jrMdpx38vDtwxFC9s_dk1ZjuD5BHahd_53neE8kxH8BCvS-BQ</recordid><startdate>20000324</startdate><enddate>20000324</enddate><creator>Adams, Mark D.</creator><creator>Celniker, Susan E.</creator><creator>Evans, Cheryl A.</creator><creator>Amanatides, Peter G.</creator><creator>Scherer, Steven E.</creator><creator>Hoskins, Roger A.</creator><creator>Galle, Richard F.</creator><creator>Wortman, Jennifer R.</creator><creator>Chen, Lin X.</creator><creator>Rogers, Yu-Hui C.</creator><creator>Blazej, Robert G.</creator><creator>Pfeiffer, Barret D.</creator><creator>Wan, Kenneth H.</creator><creator>Doyle, Clare</creator><creator>Baxter, Evan G.</creator><creator>Helt, Gregg</creator><creator>Abril, Josep F.</creator><creator>An, Hui-Jin</creator><creator>Baldwin, Danita</creator><creator>Ballew, Richard M.</creator><creator>Basu, Anand</creator><creator>Bayraktaroglu, Leyla</creator><creator>Beasley, Ellen M.</creator><creator>Beeson, Karen Y.</creator><creator>Bolshakov, Slava</creator><creator>Borkova, Dana</creator><creator>Bouck, John</creator><creator>Brokstein, Peter</creator><creator>Burtis, Kenneth C.</creator><creator>Butler, Heather</creator><creator>Cadieu, Edouard</creator><creator>Angela Center</creator><creator>Cherry, J. 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Michael ; Cawley, Simon ; Davies, Peter ; de Pablos, Beatriz ; Dodson, Kristina ; Doup, Lisa E. ; Ferraz, Concepcion ; Fleischmann, Wolfgang ; Fosler, Carl ; Gabrielian, Andrei E. ; Garg, Neha S. ; Glodek, Anna ; Gong, Fangcheng ; Guan, Ping ; Harris, Michael ; Houck, Jarrett ; Hostin, Damon ; Houston, Kathryn A. ; Howland, Timothy J. ; Jalali, Mena ; Kalush, Francis ; Ke, Zhaoxi ; Ketchum, Karen A. ; Kimmel, Bruce E. ; Kodira, Chinnappa D. ; Kraft, Cheryl ; Kravitz, Saul ; Lai, Zhongwu ; Lei, Yiding ; Li, Zhenya ; Liang, Yong ; Lin, Xiaoying ; Mattei, Bettina ; McIntosh, Tina C. ; McPherson, Duncan ; Milshina, Natalia V. ; Moy, Mee ; Murphy, Lee ; Muzny, Donna M. ; Nelson, David L. ; Nelson, David R. ; Nelson, Keith A. ; Nixon, Katherine ; Pan, Sue ; Pollard, John ; Reinert, Knut ; Skupski, Marian P. ; Spier, Eugene ; Stapleton, Mark ; Sun, Eric ; Svirskas, Robert ; Turner, Russell ; Venter, Eli ; Wang, Xin ; Wang, Zhen-Yuan ; Weissenbach, Jean ; Yang, Song ; Yao, Q. Alison ; Ye, Jane ; Zhan, Ming ; Zheng, Liansheng ; Zhong, Wenyan ; Zhou, Xiaojun ; Zhu, Shiaoping ; Zhu, Xiaohong ; Smith, Hamilton O. ; Gibbs, Richard A. ; Rubin, Gerald M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c639t-bdae2b7e049292f558bc85f9c53ba8c6c36069c306cb2e5c690c2f894745a62a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Biological Transport - genetics</topic><topic>Chromatin - genetics</topic><topic>Chromosome mapping</topic><topic>Chromosomes</topic><topic>Cloning, Molecular</topic><topic>Community Relations</topic><topic>Computational Biology</topic><topic>Contig Mapping</topic><topic>Cytochrome P-450 Enzyme System - genetics</topic><topic>DNA</topic><topic>DNA Repair - genetics</topic><topic>DNA Replication - genetics</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Euchromatin</topic><topic>Gene Library</topic><topic>Genes</topic><topic>Genes, Insect</topic><topic>Genome</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Heterochromatin - genetics</topic><topic>Insect Proteins - chemistry</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - physiology</topic><topic>Insects</topic><topic>Libraries</topic><topic>Nuclear Proteins - genetics</topic><topic>Protein Biosynthesis</topic><topic>Research Tools</topic><topic>Reviews</topic><topic>Scaffolds</topic><topic>Science and Society</topic><topic>Sequence Analysis, DNA</topic><topic>Sequencing</topic><topic>Transcription, Genetic</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adams, Mark D.</creatorcontrib><creatorcontrib>Celniker, Susan E.</creatorcontrib><creatorcontrib>Evans, Cheryl A.</creatorcontrib><creatorcontrib>Amanatides, Peter G.</creatorcontrib><creatorcontrib>Scherer, Steven E.</creatorcontrib><creatorcontrib>Hoskins, Roger A.</creatorcontrib><creatorcontrib>Galle, Richard F.</creatorcontrib><creatorcontrib>Wortman, Jennifer R.</creatorcontrib><creatorcontrib>Chen, Lin X.</creatorcontrib><creatorcontrib>Rogers, Yu-Hui C.</creatorcontrib><creatorcontrib>Blazej, Robert G.</creatorcontrib><creatorcontrib>Pfeiffer, Barret D.</creatorcontrib><creatorcontrib>Wan, Kenneth H.</creatorcontrib><creatorcontrib>Doyle, Clare</creatorcontrib><creatorcontrib>Baxter, Evan G.</creatorcontrib><creatorcontrib>Helt, Gregg</creatorcontrib><creatorcontrib>Abril, Josep F.</creatorcontrib><creatorcontrib>An, Hui-Jin</creatorcontrib><creatorcontrib>Baldwin, Danita</creatorcontrib><creatorcontrib>Ballew, Richard M.</creatorcontrib><creatorcontrib>Basu, Anand</creatorcontrib><creatorcontrib>Bayraktaroglu, Leyla</creatorcontrib><creatorcontrib>Beasley, Ellen M.</creatorcontrib><creatorcontrib>Beeson, Karen Y.</creatorcontrib><creatorcontrib>Bolshakov, Slava</creatorcontrib><creatorcontrib>Borkova, Dana</creatorcontrib><creatorcontrib>Bouck, John</creatorcontrib><creatorcontrib>Brokstein, Peter</creatorcontrib><creatorcontrib>Burtis, Kenneth C.</creatorcontrib><creatorcontrib>Butler, Heather</creatorcontrib><creatorcontrib>Cadieu, Edouard</creatorcontrib><creatorcontrib>Angela Center</creatorcontrib><creatorcontrib>Cherry, J. 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Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adams, Mark D.</au><au>Celniker, Susan E.</au><au>Evans, Cheryl A.</au><au>Amanatides, Peter G.</au><au>Scherer, Steven E.</au><au>Hoskins, Roger A.</au><au>Galle, Richard F.</au><au>Wortman, Jennifer R.</au><au>Chen, Lin X.</au><au>Rogers, Yu-Hui C.</au><au>Blazej, Robert G.</au><au>Pfeiffer, Barret D.</au><au>Wan, Kenneth H.</au><au>Doyle, Clare</au><au>Baxter, Evan G.</au><au>Helt, Gregg</au><au>Abril, Josep F.</au><au>An, Hui-Jin</au><au>Baldwin, Danita</au><au>Ballew, Richard M.</au><au>Basu, Anand</au><au>Bayraktaroglu, Leyla</au><au>Beasley, Ellen M.</au><au>Beeson, Karen Y.</au><au>Bolshakov, Slava</au><au>Borkova, Dana</au><au>Bouck, John</au><au>Brokstein, Peter</au><au>Burtis, Kenneth C.</au><au>Butler, Heather</au><au>Cadieu, Edouard</au><au>Angela Center</au><au>Cherry, J. Michael</au><au>Cawley, Simon</au><au>Davies, Peter</au><au>de Pablos, Beatriz</au><au>Dodson, Kristina</au><au>Doup, Lisa E.</au><au>Ferraz, Concepcion</au><au>Fleischmann, Wolfgang</au><au>Fosler, Carl</au><au>Gabrielian, Andrei E.</au><au>Garg, Neha S.</au><au>Glodek, Anna</au><au>Gong, Fangcheng</au><au>Guan, Ping</au><au>Harris, Michael</au><au>Houck, Jarrett</au><au>Hostin, Damon</au><au>Houston, Kathryn A.</au><au>Howland, Timothy J.</au><au>Jalali, Mena</au><au>Kalush, Francis</au><au>Ke, Zhaoxi</au><au>Ketchum, Karen A.</au><au>Kimmel, Bruce E.</au><au>Kodira, Chinnappa D.</au><au>Kraft, Cheryl</au><au>Kravitz, Saul</au><au>Lai, Zhongwu</au><au>Lei, Yiding</au><au>Li, Zhenya</au><au>Liang, Yong</au><au>Lin, Xiaoying</au><au>Mattei, Bettina</au><au>McIntosh, Tina C.</au><au>McPherson, Duncan</au><au>Milshina, Natalia V.</au><au>Moy, Mee</au><au>Murphy, Lee</au><au>Muzny, Donna M.</au><au>Nelson, David L.</au><au>Nelson, David R.</au><au>Nelson, Keith A.</au><au>Nixon, Katherine</au><au>Pan, Sue</au><au>Pollard, John</au><au>Reinert, Knut</au><au>Skupski, Marian P.</au><au>Spier, Eugene</au><au>Stapleton, Mark</au><au>Sun, Eric</au><au>Svirskas, Robert</au><au>Turner, Russell</au><au>Venter, Eli</au><au>Wang, Xin</au><au>Wang, Zhen-Yuan</au><au>Weissenbach, Jean</au><au>Yang, Song</au><au>Yao, Q. Alison</au><au>Ye, Jane</au><au>Zhan, Ming</au><au>Zheng, Liansheng</au><au>Zhong, Wenyan</au><au>Zhou, Xiaojun</au><au>Zhu, Shiaoping</au><au>Zhu, Xiaohong</au><au>Smith, Hamilton O.</au><au>Gibbs, Richard A.</au><au>Rubin, Gerald M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Genome Sequence of Drosophila melanogaster</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2000-03-24</date><risdate>2000</risdate><volume>287</volume><issue>5461</issue><spage>2185</spage><epage>2195</epage><pages>2185-2195</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ∼13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>10731132</pmid><doi>10.1126/science.287.5461.2185</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5461), p.2185-2195 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743504246 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Analysis Animals Biological Transport - genetics Chromatin - genetics Chromosome mapping Chromosomes Cloning, Molecular Community Relations Computational Biology Contig Mapping Cytochrome P-450 Enzyme System - genetics DNA DNA Repair - genetics DNA Replication - genetics Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Euchromatin Gene Library Genes Genes, Insect Genome Genomes Genomics Heterochromatin - genetics Insect Proteins - chemistry Insect Proteins - genetics Insect Proteins - physiology Insects Libraries Nuclear Proteins - genetics Protein Biosynthesis Research Tools Reviews Scaffolds Science and Society Sequence Analysis, DNA Sequencing Transcription, Genetic Yeasts |
| title | The Genome Sequence of Drosophila melanogaster |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T08%3A05%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Genome%20Sequence%20of%20Drosophila%20melanogaster&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Adams,%20Mark%20D.&rft.date=2000-03-24&rft.volume=287&rft.issue=5461&rft.spage=2185&rft.epage=2195&rft.pages=2185-2195&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.287.5461.2185&rft_dat=%3Cgale_proqu%3EA61635920%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213575895&rft_id=info:pmid/10731132&rft_galeid=A61635920&rft_jstor_id=3074811&rfr_iscdi=true |