The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells

Steroid receptors bind to site-specific response elements in chromatin and modulate gene expression in a hormone-dependent fashion. With the use of a tandem array of mouse mammary tumor virus reporter elements and a form of glucocorticoid receptor labeled with green fluorescent protein, targeting of...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2000-02, Vol.287 (5456), p.1262-1265
Hauptverfasser:	McNally, James G., Müller, Waltraud G., Walker, Dawn, Wolford, Ronald, Hager, Gordon L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological and medical sciences Cell Line, Transformed Cell lines Cell nucleus Cell Nucleus - metabolism Cell receptors Cell structures and functions Cells Chromatin Chromatin - metabolism Chromosomes Dexamethasone - metabolism Dexamethasone - pharmacology DNA DNA probes Fundamental and applied biological sciences. Psychology Genes Green Fluorescent Proteins Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors In Situ Hybridization, Fluorescence Laser beams Ligands Luminescent Proteins Mammary Tumor Virus, Mouse - genetics Mice Microscopy, Confocal Microscopy, Fluorescence Molecular and cellular biology Nucleosomes - metabolism Receptors Receptors, Glucocorticoid - metabolism Response Elements Rodents Spleen Steroids Terminal Repeat Sequences Transcripts (Written Records)
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