Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo
Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralizat...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1991-10, Vol.254 (5030), p.421-423 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Karalis, Katia Sano, Hajime Redwine, Jeffrey Listwak, Sam Wilder, Ronald L. Chrousos, George P. |
| description | Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory exudate volume and cell concentration by approximately 50 to 60 percent. CRH was detected in the inflamed area but not in the systemic circulation. Immunoreactive CRH is therefore produced in peripheral inflammatory sites where, in contrast to its systemic indirect immunosuppressive effects, it acts as an autocrine or paracrine inflammatory cytokine. |
| doi_str_mv | 10.1126/science.1925600 |
| format | Article |
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CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory exudate volume and cell concentration by approximately 50 to 60 percent. CRH was detected in the inflamed area but not in the systemic circulation. Immunoreactive CRH is therefore produced in peripheral inflammatory sites where, in contrast to its systemic indirect immunosuppressive effects, it acts as an autocrine or paracrine inflammatory cytokine.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1925600</identifier><identifier>PMID: 1925600</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Animals ; Antiserum ; Behavioral neuroscience ; Carrageenan ; Corticotropin releasing hormone ; Corticotropin-Releasing Hormone - immunology ; Corticotropin-Releasing Hormone - metabolism ; Corticotropin-Releasing Hormone - physiology ; Endocrine system ; Endocrinology ; Glucocorticoids ; Hormones ; Hypothalamic regulation ; Immune response ; Immune Sera ; Immunity (Disease) ; Immunohistochemistry ; Inflammation ; Inflammation - chemically induced ; Inflammation - metabolism ; Leukocytes ; Male ; Medical research ; Rats ; Rats, Inbred Strains ; Receptors ; Secretion ; Tumor Necrosis Factor-alpha - immunology ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>Science (American Association for the Advancement of Science), 1991-10, Vol.254 (5030), p.421-423</ispartof><rights>Copyright 1991 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1991 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Oct 18, 1991</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c658t-6691fdbeacecc86b68ce5b669fc9e66ce32cd46231e079d50b85317d9e9cd9a23</citedby><cites>FETCH-LOGICAL-c658t-6691fdbeacecc86b68ce5b669fc9e66ce32cd46231e079d50b85317d9e9cd9a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2879230$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2879230$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1925600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karalis, Katia</creatorcontrib><creatorcontrib>Sano, Hajime</creatorcontrib><creatorcontrib>Redwine, Jeffrey</creatorcontrib><creatorcontrib>Listwak, Sam</creatorcontrib><creatorcontrib>Wilder, Ronald L.</creatorcontrib><creatorcontrib>Chrousos, George P.</creatorcontrib><title>Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory exudate volume and cell concentration by approximately 50 to 60 percent. CRH was detected in the inflamed area but not in the systemic circulation. Immunoreactive CRH is therefore produced in peripheral inflammatory sites where, in contrast to its systemic indirect immunosuppressive effects, it acts as an autocrine or paracrine inflammatory cytokine.</description><subject>Animals</subject><subject>Antiserum</subject><subject>Behavioral neuroscience</subject><subject>Carrageenan</subject><subject>Corticotropin releasing hormone</subject><subject>Corticotropin-Releasing Hormone - immunology</subject><subject>Corticotropin-Releasing Hormone - metabolism</subject><subject>Corticotropin-Releasing Hormone - physiology</subject><subject>Endocrine system</subject><subject>Endocrinology</subject><subject>Glucocorticoids</subject><subject>Hormones</subject><subject>Hypothalamic regulation</subject><subject>Immune response</subject><subject>Immune Sera</subject><subject>Immunity (Disease)</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - metabolism</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical research</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors</subject><subject>Secretion</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0s1v0zAYB-AIgUY3OHMBKeIAHJbNH7UTH0sFXaWKIj56tRznTeUqsTs7Qdt_j6dEQ0UVVDlY8fvYll__kuQVRlcYE34dtAGr4QoLwjhCT5IJRoJlgiD6NJkgRHlWoJw9T85D2CEUa4KeJWcjnySbWd857Y2F1Pn0q_Jq-FnaulFtqzrn79OZ7oyzIXV1One-M9p13u2Nzb5BAyoYu01vnG9dXGdsujG_3IvkWa2aAC_H8SL5-fnTj_lNtlovlvPZKtOcFV3GucB1VYLSoHXBS15oYGWcrbUAzjVQoqspJxQDykXFUFkwivNKgNCVUIReJO-Hfffe3fYQOtmaoKFplAXXB5lP6VSwoqBRvvu3JJhhEuX_IOaIE4JYhG__gjvXexuvKwmmbJoXQkR0OaCtakAaW8fWKb0FC141sWG1idMzjKdcUPRweHaEx6-CNrb9iP9w4CPp4K7bqj4Eufz-5WS63pxMPy5OpcVidUAvj1Htmga2IGMu5usDfj1w7V0IHmq596ZV_l5iJB-yL8fsyzHMccWb8UH6soXqj3-svx7quxBj_VgmRS4IRfQ3i_QFFA</recordid><startdate>19911018</startdate><enddate>19911018</enddate><creator>Karalis, Katia</creator><creator>Sano, Hajime</creator><creator>Redwine, Jeffrey</creator><creator>Listwak, Sam</creator><creator>Wilder, Ronald L.</creator><creator>Chrousos, George P.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19911018</creationdate><title>Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo</title><author>Karalis, Katia ; Sano, Hajime ; Redwine, Jeffrey ; Listwak, Sam ; Wilder, Ronald L. ; Chrousos, George P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c658t-6691fdbeacecc86b68ce5b669fc9e66ce32cd46231e079d50b85317d9e9cd9a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Antiserum</topic><topic>Behavioral neuroscience</topic><topic>Carrageenan</topic><topic>Corticotropin releasing hormone</topic><topic>Corticotropin-Releasing Hormone - 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Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karalis, Katia</au><au>Sano, Hajime</au><au>Redwine, Jeffrey</au><au>Listwak, Sam</au><au>Wilder, Ronald L.</au><au>Chrousos, George P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1991-10-18</date><risdate>1991</risdate><volume>254</volume><issue>5030</issue><spage>421</spage><epage>423</epage><pages>421-423</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory exudate volume and cell concentration by approximately 50 to 60 percent. CRH was detected in the inflamed area but not in the systemic circulation. Immunoreactive CRH is therefore produced in peripheral inflammatory sites where, in contrast to its systemic indirect immunosuppressive effects, it acts as an autocrine or paracrine inflammatory cytokine.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>1925600</pmid><doi>10.1126/science.1925600</doi><tpages>3</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 1991-10, Vol.254 (5030), p.421-423 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; MEDLINE; JSTOR |
| subjects | Animals Antiserum Behavioral neuroscience Carrageenan Corticotropin releasing hormone Corticotropin-Releasing Hormone - immunology Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - physiology Endocrine system Endocrinology Glucocorticoids Hormones Hypothalamic regulation Immune response Immune Sera Immunity (Disease) Immunohistochemistry Inflammation Inflammation - chemically induced Inflammation - metabolism Leukocytes Male Medical research Rats Rats, Inbred Strains Receptors Secretion Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - physiology |
| title | Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo |
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