Stereoselective reduction of ketones by Daucus carota hairy root cultures

Stereoselective reduction of ketones by Daucus carota hairy root cultures

Reduction of acetophenone by Daucus carota hairy root cultures afforded (S)-phenylethanol in high yield (96%) and excellent enantiomeric excess (ee>or=98%). Aromatic ketones, keto esters, and a simple aliphatic ketone were reduced with good stereoselectivity (ee=62-98%) and moderate to high chemi...

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Veröffentlicht in:Biotechnology letters 2005-05, Vol.27 (10), p.713-716
Hauptverfasser: CARON, Dave, COUGHLAN, Andrew P, SIMARD, Mathieu, BERNIER, Jonathan, PICHE, Yves, CHENEVERT, Robert
Format: Artikel
Sprache:eng
Schlagworte:
Acetophenones - chemistry
Acetophenones - metabolism
Biological and medical sciences
Biotechnology
Biotransformation
Carrots
Daucus carota
Daucus carota - metabolism
Esters
Fundamental and applied biological sciences. Psychology
Ketones
Ketones - chemistry
Ketones - metabolism
Molecular Structure
Phenylethyl Alcohol - chemistry
Phenylethyl Alcohol - metabolism
Plant Roots - metabolism
Stereoisomerism
Tissue Culture Techniques
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Zusammenfassung:Reduction of acetophenone by Daucus carota hairy root cultures afforded (S)-phenylethanol in high yield (96%) and excellent enantiomeric excess (ee>or=98%). Aromatic ketones, keto esters, and a simple aliphatic ketone were reduced with good stereoselectivity (ee=62-98%) and moderate to high chemical yields (25-90%).
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-005-5187-y