Structure and expression of a human oxytocin receptor
JUST before the onset of labour, uterine myometrium becomes extremely sensitive to oxytocin 1 for which it is a primary target tissue, because of a dramatic increase in the number of oxytocin receptors 2,3 . We report here the structure and expression of the human oxytocin receptor complementary DNA...
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| Veröffentlicht in: | Nature (London) 1992-04, Vol.356 (6369), p.526-529 |
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| creator | Kimura, Tadashi Tanizawa, Osamu Mori, Kensaku Brownstein, Michael J. Okayama, Hiroto |
| description | JUST before the onset of labour, uterine myometrium becomes extremely sensitive to oxytocin
1
for which it is a primary target tissue, because of a dramatic increase in the number of oxytocin receptors
2,3
. We report here the structure and expression of the human oxytocin receptor complementary DNA isolated by expression cloning. The encoded receptor is a 388-amino-acidpolypeptide with
7
transmembrane domains typical of G protein-coupled receptors. The oxytocin receptor, expressed in
Xenopus
oocytes, specifically responds to oxytocin and induces an inward membrane current. Messenger RNAs for the receptor are of two sizes, 3.6 kilobases in breast, and 4.4 kilobases in ovary, uterine endometrium and myometrium. The mRNA level in the myometrium is very high at term. We conclude that the increase in receptor number in the myometrium at labour is, at least in part, due to the increase in mRNA. |
| doi_str_mv | 10.1038/356526a0 |
| format | Article |
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1
for which it is a primary target tissue, because of a dramatic increase in the number of oxytocin receptors
2,3
. We report here the structure and expression of the human oxytocin receptor complementary DNA isolated by expression cloning. The encoded receptor is a 388-amino-acidpolypeptide with
7
transmembrane domains typical of G protein-coupled receptors. The oxytocin receptor, expressed in
Xenopus
oocytes, specifically responds to oxytocin and induces an inward membrane current. Messenger RNAs for the receptor are of two sizes, 3.6 kilobases in breast, and 4.4 kilobases in ovary, uterine endometrium and myometrium. The mRNA level in the myometrium is very high at term. We conclude that the increase in receptor number in the myometrium at labour is, at least in part, due to the increase in mRNA.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/356526a0</identifier><identifier>PMID: 1313946</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Arginine Vasopressin - pharmacology ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; Cell receptors ; Cell structures and functions ; Cloning ; Cloning, Molecular ; Deoxyribonucleic acid ; DNA ; Dose-Response Relationship, Drug ; Female ; Fundamental and applied biological sciences. Psychology ; genes ; Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors ; Humanities and Social Sciences ; Humans ; letter ; Membrane Potentials - drug effects ; Molecular and cellular biology ; Molecular Sequence Data ; multidisciplinary ; Myometrium - metabolism ; Oocytes - physiology ; ovaries ; Oxytocin - pharmacology ; Pregnancy ; Receptors, Angiotensin - chemistry ; Receptors, Angiotensin - genetics ; Receptors, Angiotensin - metabolism ; Receptors, Oxytocin ; RNA, Messenger - analysis ; Science ; Science (multidisciplinary) ; Sequence Homology, Nucleic Acid ; uterus ; Xenopus</subject><ispartof>Nature (London), 1992-04, Vol.356 (6369), p.526-529</ispartof><rights>Springer Nature Limited 1992</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Apr 9, 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-39445165e6f5318901111c0e3e3f40f4b5f6d5da30cffa37e9a4278493e20afe3</citedby><cites>FETCH-LOGICAL-c431t-39445165e6f5318901111c0e3e3f40f4b5f6d5da30cffa37e9a4278493e20afe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/356526a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/356526a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5247460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1313946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, Tadashi</creatorcontrib><creatorcontrib>Tanizawa, Osamu</creatorcontrib><creatorcontrib>Mori, Kensaku</creatorcontrib><creatorcontrib>Brownstein, Michael J.</creatorcontrib><creatorcontrib>Okayama, Hiroto</creatorcontrib><title>Structure and expression of a human oxytocin receptor</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>JUST before the onset of labour, uterine myometrium becomes extremely sensitive to oxytocin
1
for which it is a primary target tissue, because of a dramatic increase in the number of oxytocin receptors
2,3
. We report here the structure and expression of the human oxytocin receptor complementary DNA isolated by expression cloning. The encoded receptor is a 388-amino-acidpolypeptide with
7
transmembrane domains typical of G protein-coupled receptors. The oxytocin receptor, expressed in
Xenopus
oocytes, specifically responds to oxytocin and induces an inward membrane current. Messenger RNAs for the receptor are of two sizes, 3.6 kilobases in breast, and 4.4 kilobases in ovary, uterine endometrium and myometrium. The mRNA level in the myometrium is very high at term. We conclude that the increase in receptor number in the myometrium at labour is, at least in part, due to the increase in mRNA.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genes</subject><subject>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Membrane Potentials - drug effects</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Myometrium - metabolism</subject><subject>Oocytes - physiology</subject><subject>ovaries</subject><subject>Oxytocin - pharmacology</subject><subject>Pregnancy</subject><subject>Receptors, Angiotensin - chemistry</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Receptors, Angiotensin - metabolism</subject><subject>Receptors, Oxytocin</subject><subject>RNA, Messenger - analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>uterus</subject><subject>Xenopus</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUlLBDEQhYMoOi7gHxAaEZdDayWpLHMUcQPBg3puYqaiLTPdY9IN-u_NMKOCgtYlBe_jvQqPsW0OxxykPZFKK6EdLLEBR6NL1NYsswGAsCVYqdfYekovAKC4wVW2yiWXQ9QDpu662Puuj1S4ZlTQ2zRSSnXbFG0oXPHcT1xe39671tdNEcnTtGvjJlsJbpxoa_FusIeL8_uzq_Lm9vL67PSm9Ch5V-YIVFwr0kFJbofA83ggSTIgBHxUQY_UyEnwIThpaOhQGItDSQJcILnBDua-09i-9pS6alInT-Oxa6jtU2VQojVCi0zu_00Ka0Fy_i_INTca0GZw9wf40vaxyd-tBCCiEHIWeziHfGxTihSqaawnLr5XHKpZM9VnMxndWfj1jxMafYPzKrK-t9Bd8m4comt8nb4wJdCgntkczbGUleaJ4vdZvyI_AKAwnyE</recordid><startdate>19920409</startdate><enddate>19920409</enddate><creator>Kimura, Tadashi</creator><creator>Tanizawa, Osamu</creator><creator>Mori, Kensaku</creator><creator>Brownstein, Michael J.</creator><creator>Okayama, Hiroto</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7T3</scope><scope>M81</scope><scope>7X8</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>19920409</creationdate><title>Structure and expression of a human oxytocin receptor</title><author>Kimura, Tadashi ; 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1
for which it is a primary target tissue, because of a dramatic increase in the number of oxytocin receptors
2,3
. We report here the structure and expression of the human oxytocin receptor complementary DNA isolated by expression cloning. The encoded receptor is a 388-amino-acidpolypeptide with
7
transmembrane domains typical of G protein-coupled receptors. The oxytocin receptor, expressed in
Xenopus
oocytes, specifically responds to oxytocin and induces an inward membrane current. Messenger RNAs for the receptor are of two sizes, 3.6 kilobases in breast, and 4.4 kilobases in ovary, uterine endometrium and myometrium. The mRNA level in the myometrium is very high at term. We conclude that the increase in receptor number in the myometrium at labour is, at least in part, due to the increase in mRNA.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1313946</pmid><doi>10.1038/356526a0</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1992-04, Vol.356 (6369), p.526-529 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743487262 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Amino Acid Sequence Animals Arginine Vasopressin - pharmacology Base Sequence Biological and medical sciences Blotting, Northern Cell receptors Cell structures and functions Cloning Cloning, Molecular Deoxyribonucleic acid DNA Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology genes Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humanities and Social Sciences Humans letter Membrane Potentials - drug effects Molecular and cellular biology Molecular Sequence Data multidisciplinary Myometrium - metabolism Oocytes - physiology ovaries Oxytocin - pharmacology Pregnancy Receptors, Angiotensin - chemistry Receptors, Angiotensin - genetics Receptors, Angiotensin - metabolism Receptors, Oxytocin RNA, Messenger - analysis Science Science (multidisciplinary) Sequence Homology, Nucleic Acid uterus Xenopus |
| title | Structure and expression of a human oxytocin receptor |
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