Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition

The three-dimensional structure of a specific antibody (Fab 17/9) to a peptide immunogen from influenza virus hemagglutinin [HA1(75-110)] and two independent crystal complexes of this antibody with bound peptide (Tyr$^{P100}$-Leu$^{P108}$) have been determined by x-ray crystallographic techniques at...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-02, Vol.255 (5047), p.959-965
Hauptverfasser:	Rini, James M., Schulze-Gahmen, Ursula, Wilson, Ian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Antibodies, immunoglobulins Antibodies, Monoclonal - ultrastructure Antigen-Antibody Reactions Antigens Atoms Binding sites Biological and medical sciences Biology Conformity Crystals Electron density Energy Fundamental and applied biological sciences. Psychology Fundamental immunology Hemagglutinins, Viral - immunology Hydrogen Bonding Hydrogen bonds Immune recognition Immunity (Disease) Immunoglobulin Fab Fragments - ultrastructure Immunoglobulin G - ultrastructure In Vitro Techniques Influenza A virus - immunology influenza virus Kinetics Mice Models, Molecular Molecular immunology Molecular Sequence Data Molecular structure Molecules Motion Peptides - chemistry Peptides - immunology Personality Protein Binding Protein Conformation Protein structure Proteins Research Article Structure Surface areas Thermodynamics Transcripts (Written Records) X-ray crystallography X-Ray Diffraction
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