Increased Spontaneous Polyclonal Activation of B Lymphocytes in Mice with Spontaneous Autoimmune Disease

Early in life, mice of four kinds [NZB, (NZB X NZW)F1, MRL/1, and male BXSB] with autoimmune disease spontaneously produced far more (greater than 3 S.D.) anti-hapten antibody-forming cells in spleens and greater concentrations of anti-hapten antibodies in sera than immunologically normal strains of...

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Veröffentlicht in:	The Journal of immunology (1950) 1978-12, Vol.121 (6), p.2213-2219
Hauptverfasser:	Izui, Shozo, McConahey, Patricia J, Dixon, Frank J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies Autoimmune Diseases - immunology B-Lymphocytes - immunology Binding Sites DNA - immunology Female Glycoproteins - immunology Haptens Hemolytic Plaque Technique Immunoglobulin M Male Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred NZB Spleen - immunology Time Factors Trinitrobenzenes - immunology
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