Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine

Riboswitches are genetic regulatory elements found in the 5′ untranslated region of messenger RNA that act in the absence of protein cofactors 1 , 2 . They are broadly distributed across bacteria and account for the regulation of more than 2% of all genes in Bacillus subtilis , underscoring their im...

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