Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

After activation, CD4+ helper T (TH) cells differentiate into distinct effector subsets that are characterized by their unique cytokine expression and immunoregulatory function. During this differentiation, TH1 and TH2 cells produce interferon- and interleukin (IL)-4, respectively, as autocrine fact...

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Veröffentlicht in:	Nature 2007-07, Vol.448 (7152), p.480-483
Hauptverfasser:	Zhang, Yongliang, Watowich, Stephanie S, Nurieva, Roza, Martinez, Gustavo, Jetten, Anton M, Yang, Xuexian O, Ma, Li, Panopoulos, Athanasia D, Dong, Chen, Schluns, Kimberly, Tian, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autocrine Communication Autocrine mechanisms Biological and medical sciences Cell Differentiation Cellular biology Cytokines Forkhead Transcription Factors - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Genetics of the immune response Humanities and Social Sciences Immunobiology Immunology Inflammation - immunology Inflammation - metabolism Inflammatory diseases Interleukin-17 - biosynthesis Interleukin-17 - immunology Interleukin-17 - metabolism Interleukin-21 Interleukin-6 - metabolism Interleukins - deficiency Interleukins - immunology Interleukins - metabolism letter Lymphocyte Activation Mice multidisciplinary Nuclear Receptor Subfamily 1, Group F, Member 3 Properties Receptors, Retinoic Acid - metabolism Receptors, Thyroid Hormone - metabolism Rodents Science Science (multidisciplinary) Signal transduction STAT3 Transcription Factor - metabolism T cells T-Lymphocytes, Helper-Inducer - cytology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism
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