Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions
Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. M...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2001-08, Vol.293 (5531), p.872-875 |
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| creator | Marín, Oscar Yaron, Avraham Bagri, Anil Tessier-Lavigne, Marc John L. R. Rubenstein |
| description | Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. Migrating interneurons expressing neuropilins, receptors for semaphorins, are directed to the cortex; those lacking them go to the striatum. Loss of neuropilin function increases the number of interneurons that migrate into the striatum. These observations reveal a mechanism by which neuropilins mediate sorting of distinct neuronal populations into different brain structures, and provide evidence that, in addition to guiding axons, these receptors also control neuronal migration in the central nervous system. |
| doi_str_mv | 10.1126/science.1061891 |
| format | Article |
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These observations reveal a mechanism by which neuropilins mediate sorting of distinct neuronal populations into different brain structures, and provide evidence that, in addition to guiding axons, these receptors also control neuronal migration in the central nervous system.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1061891</identifier><identifier>PMID: 11486090</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Anatomy ; Animal embryology ; Animals ; Axons ; Basal Ganglia - cytology ; Basal Ganglia - embryology ; Basal Ganglia - metabolism ; Biochemistry ; Biochemistry and metabolism ; Biological and medical sciences ; Brain ; Brain chemistry ; Cell aggregates ; Cell Movement ; Central nervous system ; Cerebral Cortex - cytology ; Cerebral Cortex - embryology ; Cerebral Cortex - metabolism ; Corpus Striatum - cytology ; Corpus Striatum - embryology ; Corpus Striatum - metabolism ; COS Cells ; Culture Techniques ; Dendrites ; Fundamental and applied biological sciences. Psychology ; Genetic research ; Genetically modified mice ; Glycoproteins - metabolism ; Green Fluorescent Proteins ; Interneurons ; Interneurons - metabolism ; Interneurons - physiology ; Ligands ; Luminescent Proteins - metabolism ; Membrane Proteins - metabolism ; Mice ; Mice, Transgenic ; Migration ; Mutation ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Nervous system ; Neurology ; Neurons ; neuropilin ; Neuropilin-1 ; Neuropilins ; Receptors ; Recombinant Proteins - metabolism ; Semaphorin-3A ; Semaphorins ; Signal Transduction ; Telencephalon ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 2001-08, Vol.293 (5531), p.872-875</ispartof><rights>Copyright 2001 American Association for the Advancement of Science</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Aug 3, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c800t-7c0a4b62b25279f2d9e5eb2bd3c677d172d6a7d22cbdb55a2b6bf02a639acfe93</citedby><cites>FETCH-LOGICAL-c800t-7c0a4b62b25279f2d9e5eb2bd3c677d172d6a7d22cbdb55a2b6bf02a639acfe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3084149$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3084149$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1066073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11486090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marín, Oscar</creatorcontrib><creatorcontrib>Yaron, Avraham</creatorcontrib><creatorcontrib>Bagri, Anil</creatorcontrib><creatorcontrib>Tessier-Lavigne, Marc</creatorcontrib><creatorcontrib>John L. R. Rubenstein</creatorcontrib><title>Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. Migrating interneurons expressing neuropilins, receptors for semaphorins, are directed to the cortex; those lacking them go to the striatum. Loss of neuropilin function increases the number of interneurons that migrate into the striatum. 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Rubenstein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c800t-7c0a4b62b25279f2d9e5eb2bd3c677d172d6a7d22cbdb55a2b6bf02a639acfe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anatomy</topic><topic>Animal embryology</topic><topic>Animals</topic><topic>Axons</topic><topic>Basal Ganglia - cytology</topic><topic>Basal Ganglia - embryology</topic><topic>Basal Ganglia - metabolism</topic><topic>Biochemistry</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain chemistry</topic><topic>Cell aggregates</topic><topic>Cell Movement</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - embryology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Corpus Striatum - cytology</topic><topic>Corpus Striatum - embryology</topic><topic>Corpus Striatum - metabolism</topic><topic>COS Cells</topic><topic>Culture Techniques</topic><topic>Dendrites</topic><topic>Fundamental and applied biological sciences. 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R. Rubenstein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2001-08-03</date><risdate>2001</risdate><volume>293</volume><issue>5531</issue><spage>872</spage><epage>875</epage><pages>872-875</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. Migrating interneurons expressing neuropilins, receptors for semaphorins, are directed to the cortex; those lacking them go to the striatum. Loss of neuropilin function increases the number of interneurons that migrate into the striatum. These observations reveal a mechanism by which neuropilins mediate sorting of distinct neuronal populations into different brain structures, and provide evidence that, in addition to guiding axons, these receptors also control neuronal migration in the central nervous system.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>11486090</pmid><doi>10.1126/science.1061891</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2001-08, Vol.293 (5531), p.872-875 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743473392 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Anatomy Animal embryology Animals Axons Basal Ganglia - cytology Basal Ganglia - embryology Basal Ganglia - metabolism Biochemistry Biochemistry and metabolism Biological and medical sciences Brain Brain chemistry Cell aggregates Cell Movement Central nervous system Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - metabolism Corpus Striatum - cytology Corpus Striatum - embryology Corpus Striatum - metabolism COS Cells Culture Techniques Dendrites Fundamental and applied biological sciences. Psychology Genetic research Genetically modified mice Glycoproteins - metabolism Green Fluorescent Proteins Interneurons Interneurons - metabolism Interneurons - physiology Ligands Luminescent Proteins - metabolism Membrane Proteins - metabolism Mice Mice, Transgenic Migration Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neurology Neurons neuropilin Neuropilin-1 Neuropilins Receptors Recombinant Proteins - metabolism Semaphorin-3A Semaphorins Signal Transduction Telencephalon Vertebrates: nervous system and sense organs |
| title | Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions |
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