Sequence and analysis of chromosome 2 of Dictyostelium discoideum
The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein codin...
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| Veröffentlicht in: | Nature (London) 2002-07, Vol.418 (6893), p.79-85 |
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| creator | GLÖCKNER, Gernot EICHINGER, Ludwig GULGO, Roderic KUMPF, Kal TUNGGAL, Budl COX, Edward QUAIL, Michael A PLATZER, Matthias ROSENTHAL, André WOEGEL, Angelika A SZAFRANSKI, Karol PACHEHAT, Justin A BANKIER, Alan T DEAR, Paul H LEHMANN, Rüdiger BAUMGART, Cornella PARRA, Genis ABRIL, Josep F |
| description | The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb). If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes. This analysis strengthens the view that the evolutionary position of D. discoideum is located before the branching of metazoa and fungi but after the divergence of the plant kingdom, placing it close to the base of metazoan evolution. |
| doi_str_mv | 10.1038/nature00847 |
| format | Article |
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Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb). If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes. This analysis strengthens the view that the evolutionary position of D. discoideum is located before the branching of metazoa and fungi but after the divergence of the plant kingdom, placing it close to the base of metazoan evolution.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature00847</identifier><identifier>PMID: 12097910</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Animals ; Bacteria ; Base Composition ; Biological and medical sciences ; Chromatin. Chromosome ; Chromosomes ; Chromosomes - genetics ; Chromosomes, Artificial, Yeast - genetics ; Dictyostelium - classification ; Dictyostelium - genetics ; Dictyostelium discoideum ; Evolution, Molecular ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Fungal - genetics ; Genes, Plant - genetics ; Genes, Protozoan - genetics ; Genomics ; Humans ; Metazoa ; Molecular and cellular biology ; Molecular genetics ; Phylogeny ; Physical Chromosome Mapping ; Protein Structure, Tertiary ; Protozoan Proteins - chemistry ; Protozoan Proteins - genetics ; RNA, Transfer - genetics ; Saccharomyces cerevisiae ; Schizosaccharomyces pombe ; Sequence Analysis, DNA ; Sequence Homology ; Vertebrates - genetics</subject><ispartof>Nature (London), 2002-07, Vol.418 (6893), p.79-85</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Jul 4, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c746t-e32e9400180165e56cdab08fff83e5f544b97f333ab0d0b6c2345eff6361c4803</citedby><cites>FETCH-LOGICAL-c746t-e32e9400180165e56cdab08fff83e5f544b97f333ab0d0b6c2345eff6361c4803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13744934$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12097910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GLÖCKNER, Gernot</creatorcontrib><creatorcontrib>EICHINGER, Ludwig</creatorcontrib><creatorcontrib>GULGO, Roderic</creatorcontrib><creatorcontrib>KUMPF, Kal</creatorcontrib><creatorcontrib>TUNGGAL, Budl</creatorcontrib><creatorcontrib>COX, Edward</creatorcontrib><creatorcontrib>QUAIL, Michael A</creatorcontrib><creatorcontrib>PLATZER, Matthias</creatorcontrib><creatorcontrib>ROSENTHAL, André</creatorcontrib><creatorcontrib>WOEGEL, Angelika A</creatorcontrib><creatorcontrib>SZAFRANSKI, Karol</creatorcontrib><creatorcontrib>PACHEHAT, Justin A</creatorcontrib><creatorcontrib>BANKIER, Alan T</creatorcontrib><creatorcontrib>DEAR, Paul H</creatorcontrib><creatorcontrib>LEHMANN, Rüdiger</creatorcontrib><creatorcontrib>BAUMGART, Cornella</creatorcontrib><creatorcontrib>PARRA, Genis</creatorcontrib><creatorcontrib>ABRIL, Josep F</creatorcontrib><creatorcontrib>Dictyostelium Genome Sequencing Consortium</creatorcontrib><title>Sequence and analysis of chromosome 2 of Dictyostelium discoideum</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb). If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes. 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Chromosome</topic><topic>Chromosomes</topic><topic>Chromosomes - genetics</topic><topic>Chromosomes, Artificial, Yeast - genetics</topic><topic>Dictyostelium - classification</topic><topic>Dictyostelium - genetics</topic><topic>Dictyostelium discoideum</topic><topic>Evolution, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genes, Fungal - genetics</topic><topic>Genes, Plant - genetics</topic><topic>Genes, Protozoan - genetics</topic><topic>Genomics</topic><topic>Humans</topic><topic>Metazoa</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Phylogeny</topic><topic>Physical Chromosome Mapping</topic><topic>Protein Structure, Tertiary</topic><topic>Protozoan Proteins - chemistry</topic><topic>Protozoan Proteins - genetics</topic><topic>RNA, Transfer - genetics</topic><topic>Saccharomyces cerevisiae</topic><topic>Schizosaccharomyces pombe</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology</topic><topic>Vertebrates - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GLÖCKNER, Gernot</creatorcontrib><creatorcontrib>EICHINGER, Ludwig</creatorcontrib><creatorcontrib>GULGO, Roderic</creatorcontrib><creatorcontrib>KUMPF, 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2 of Dictyostelium discoideum</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>2002-07-04</date><risdate>2002</risdate><volume>418</volume><issue>6893</issue><spage>79</spage><epage>85</epage><pages>79-85</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb). If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes. This analysis strengthens the view that the evolutionary position of D. discoideum is located before the branching of metazoa and fungi but after the divergence of the plant kingdom, placing it close to the base of metazoan evolution.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>12097910</pmid><doi>10.1038/nature00847</doi><tpages>7</tpages></addata></record> |
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| ispartof | Nature (London), 2002-07, Vol.418 (6893), p.79-85 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_743472078 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Animals Bacteria Base Composition Biological and medical sciences Chromatin. Chromosome Chromosomes Chromosomes - genetics Chromosomes, Artificial, Yeast - genetics Dictyostelium - classification Dictyostelium - genetics Dictyostelium discoideum Evolution, Molecular Fundamental and applied biological sciences. Psychology Genes Genes, Fungal - genetics Genes, Plant - genetics Genes, Protozoan - genetics Genomics Humans Metazoa Molecular and cellular biology Molecular genetics Phylogeny Physical Chromosome Mapping Protein Structure, Tertiary Protozoan Proteins - chemistry Protozoan Proteins - genetics RNA, Transfer - genetics Saccharomyces cerevisiae Schizosaccharomyces pombe Sequence Analysis, DNA Sequence Homology Vertebrates - genetics |
| title | Sequence and analysis of chromosome 2 of Dictyostelium discoideum |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T00%3A54%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sequence%20and%20analysis%20of%20chromosome%202%20of%20Dictyostelium%20discoideum&rft.jtitle=Nature%20(London)&rft.au=GL%C3%96CKNER,%20Gernot&rft.aucorp=Dictyostelium%20Genome%20Sequencing%20Consortium&rft.date=2002-07-04&rft.volume=418&rft.issue=6893&rft.spage=79&rft.epage=85&rft.pages=79-85&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/nature00847&rft_dat=%3Cgale_proqu%3EA187545981%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204505057&rft_id=info:pmid/12097910&rft_galeid=A187545981&rfr_iscdi=true |